Skip to main content
SpringerLink
Log in
Book cover

Fibrin Sealant in Operative Medicine pp 27–38Cite as

Properties of Different Tissue Sealants with Special Emphasis on Fibrinogen-Based Preparations

  • Conference paper

Abstract

Different tissue sealants are described with special emphasis on the performance of different fibrinogen-based sealants. Therefore the biochemical properties of four different fibrinogen-based tissue adhesives are compared in detail. The major difference is in clot structure — coarse versus fine. Related to this structural difference are additional dissimilar properties. The coarse type fibrin sealant proved to be superior in tensile strength, cell compatibility and fibroblastic proliferation.

This is a preview of subscription content, log in via an institution.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ferry JD, Morrison PR (1947) Preparation and properties of serum and plasma proteins. VIII. The conversion of human fibrinogen to fibrin under various conditions. J Amer Chem Soc 69:388–400.

    Article  CAS  Google Scholar 

  2. Wolf G, Stammberger H (1984) Erste Berichte über die Anwendung eines autogenen Gewebeklebers in der Hals Nasen Ohrenheilkunde. HNO 32:1–4

    Google Scholar 

  3. Redl H, Schlag G, Dinges HP (1985) Vergleich zweier Fibrinkleber. Einfluß ionischer Zusätze auf Fibrinstruktur sowie Morphologie und Wachstum menschlicher Fibroblasten. Med Welt 36: 769–776

    CAS  Google Scholar 

  4. Redl H, Stank G, Hirschl A, Schlag G (1982) Fibrinkleber-Antibiotika-Gemische Festigkeit und Elutionsverhalten. In: Cotta H, Braun A (eds) Fibrinkleber in Orthopädie und Traumatologie. Thieme, Stuttgart, pp 178–181

    Google Scholar 

  5. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55–63

    Article  PubMed  CAS  Google Scholar 

  6. Bale MD, Müller MF, Ferry JD (1985) Rheological studies of creep and creep recovery of unligated fibrin clots: comparison of clots prepared with thrombin and ancord. Biopolymers 24: 461–482

    Article  PubMed  CAS  Google Scholar 

  7. Ross R (1968) The fibroblast and wound repair. Biol Rev 43:51–96

    Article  PubMed  CAS  Google Scholar 

  8. Blombäck B, Okada M, Forslind B, Larsson UT (1984) Fibrin gels as biological filters and interfaces. Biorheology 21:93–104

    PubMed  Google Scholar 

  9. Seelich T, Redl HT (1980) Theoretische Grundlagen des Fibrinklebers. In: Schimpf K (ed) Fibrinogen, Fibrin und Fibrinkleber. F K Schattauer, Stuttgart, pp 199–208

    Google Scholar 

  10. Kamykowski GW, Mosher DF, Lorand L, Ferry JDT (1981) Modification of shear modulus and creep compliance of fibrin by fibronectin. Biophys Chem 13:25–28

    Article  PubMed  CAS  Google Scholar 

  11. Nelb GW, Gerth C, Ferry JD, Lorand L (1976) Biophys Chem 5:377

    Article  PubMed  CAS  Google Scholar 

  12. Beck E, Duckert F, Vogel A, Ernst M (1961) The influence of fibrin stabilizing factor on the growth of fibroblasts in vitro and wound healing. Thromb Diath Haemorrh 6:485–491

    PubMed  CAS  Google Scholar 

  13. Spängier HP, Braun F (1983) Fibrinklebung in der operativen Medizin. Edition Medizin, Verlag Weinheim, Deerfield Beach, Florida, Basel

    Google Scholar 

  14. Scheele J (1984) Fibrinklebung. Springer-Verlag, Berlin, Heidelberg, New York

    Book  Google Scholar 

  15. Köstering H, Kasten U, Artmann U, Ruskowski H, Beyer JM (1981) Behandlung von Hautnekrosen nach der Extravasation von Zytostatika mit Fibrinkleber. In: Blümel G, Haas S (eds) Mikrozirkulation und Prostaglandinstoffwechsel. Interaktion von Blutgerinnung und Fibrinolyse mit anderen proteolytischen Enzymsystemen. Neues über Fibrinogen, Fibrin und Fibrinkleber. Schattauerverlag, Stuttgart, pp 349–351

    Google Scholar 

  16. Rendl KH, Staindl O, Zeiger J, Chmelizek-Feurstein CT (1980) Die Hauttransplantation mit Fibrinkleber beim Ulcus cruris. Akt Dermatol 6:199–203

    Google Scholar 

  17. Beck E, Duckert F, Vogel A, Ernst M (1962) Der Einfluß des fibrinstabilisierenden Faktors (FSF) auf Funktion und Morphologie von Fibroblasten in vitro. Z Zellforsch 57:327–346

    Article  PubMed  CAS  Google Scholar 

  18. Bruhn HD, Christopers E, Pohl J, Scholl G (1980) Regulation der Fibroblastenproliferierung durch Fibrinogen Fibrin, Fibronectin und Faktor XIII. In: Schimpf K (ed) Fibronogen, Fibrin und Fibrinkleber. F K Schattauer-Verlag, Stuttgart, pp 217–226

    Google Scholar 

  19. Turowski G, Schaadt M, Bartheis M, Diehl V, Poliwada H (1980) Unterschiedlicher Einfluß von Fibrinogen und Faktor XIII auf das Wachstum von Primär- und Kulturfibroblasten. In: Schimpf K (ed) Fibrinogen, Fibrin und Fibrinkleber. F K Schattauer-Verlag, Stuttgart, pp 227–237

    Google Scholar 

  20. Knoche H, Schmitt G (1976) Autoradiographische Untersuchungen über den Einfluß des Faktors XIII auf die Wundheilung im Tierexperiment. Arzneimittelforsch — Drug Res 26:547–551

    CAS  Google Scholar 

  21. Bruhn HD, Pohl J (1981) Growth regulation of fibroblasts by thrombin, factor XIII and fibronectin. Klin Wochenschr 59:145–146

    Article  PubMed  CAS  Google Scholar 

  22. Kasai S, Kunimoto T, Nitta J (1983) Cross-linked of fibrin by activated factor XIII stimulated attachment, morphological changes and proliferation of fibroblasts. Biomed Res 4:155–160

    CAS  Google Scholar 

  23. Hashimoto T, Marks R (1984) Factor XIII inhibits epidermal cell migration in vitro. J Invest Dermatol 83:441–444

    Article  PubMed  CAS  Google Scholar 

  24. Hamm KD, Beer R (1985) Klebefestigkeitsuntersuchungen an biologischen Gewebeklebern. Z Exp Chir Transplant Künstliche Organe 18:281–288

    PubMed  CAS  Google Scholar 

  25. Stoppa R, Henry X, Odimba E, Verhaeghe P, Largueche S, Myon Y (1980) Dacron tulle prosthesis and biological glue in the surgical treatment of incisional hernias. Nouv Presse Med 6:3541–3545

    Google Scholar 

  26. Vandor E, Jancsar L, Mozsary P, Reffy A, Demel Z (1980) Experience about the application of gelatin resorcinol formaldehyde tissue adhesive in experimental ruptured liver injury. Z Exp Chir Transplant Künstliche Organe 13:52–58

    CAS  Google Scholar 

  27. Bachet J, Gigou F, Laurian C, Bical O, Goudot B, Guilmet D (1981) 4-year clinical experience with the gelatin-resorcinol-formol biological glue in acute aortic dissection. J Thorac Cardiovasc Surg 83: 212–217

    Google Scholar 

Download references

Authors
  1. H. Redl
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Schlag
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Ludwig-Boltzmann-Institut für experimentelle Traumatologie, Donaueschingenstraße 13, A-1200, Vienna, Austria

    Günther Schlag  & Heinz Redl  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Redl, H., Schlag, G. (1986). Properties of Different Tissue Sealants with Special Emphasis on Fibrinogen-Based Preparations. In: Schlag, G., Redl, H. (eds) Fibrin Sealant in Operative Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71633-1_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71633-1_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17141-6

  • Online ISBN: 978-3-642-71633-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation