Animal Studies as for the Problem of the Bronchial Fistula
An animal study on the closure of bronchopleural fistulas is reported. Fibrin sealant (Tissucol) was combined with decalcified spongiosa. This combination was introduced bronchoscopically into central bronchus fistulas that had been created experimentally in dogs. In 10 mongrels the fistulas were closed immediately, healing was then observed endoscopically and histologically. There was rapid incorporation of the implants. In the long-term experiment fibrin and spongiosa were completely resorbed and the experimental fistula was healed. The experiment allows the conclusion that endoscopic closure of fistulas is possible regardless of the fistula’s diameter, and that this method should also be tested in human patients.
Key wordsBronchopleural fistula endoscopic sealing fibrin sealant spongiosa — block
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