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Liver Lesions in B6C3F1 Mice: The National Toxicology Program, Experience and Position

  • Conference paper
Mouse Liver Tumors

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 10))

Abstract

The spectrum of hepatocellular proliferative lesions in B6C3F1 (C57BL/6N × C3H/HeN MTV-) mice used in National Toxicology Program (NTP) two-year carcinogenicity studies includes foci of cellular alteration, adenoma, carcinoma, and hepatoblastoma. The diagnosis of hepatocellular hyperplasia is reserved for those non-neoplastic proliferative lesions which are believed to occur secondary to necrosis or a degenerative process in the liver. Diagnostic criteria, similar to those previously published, are used during the NTP peer review of these lesions. Incidences of liver tumors in control mice have been established from the NTP database and the frequency of enhanced liver tumor responses in treated mice has been determined based on 278 two-year carcinogenicity studies. Although alternative rodent strains are being examined, at the present time there is no acceptable alternative to the B6C3F1 mouse for NTP carcinogenicity studies. Interim sacrifices and “stop” studies are incorporated into two-year studies to gain knowledge about the biological behavior of mouse liver neoplasia. Also, data are being gathered relative to the pattern of oncogene activation in spontaneous and chemically induced liver tumors in B6C3F1 mice.

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Author information

Authors and Affiliations

  1. National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    R. R. Maronpot, J. K. Haseman, G. A. Boorman, S. E. Eustis, G. N. Rao & J. E. Huff

Authors
  1. R. R. Maronpot
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  2. J. K. Haseman
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  3. G. A. Boorman
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  4. S. E. Eustis
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  5. G. N. Rao
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  6. J. E. Huff
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers

  2. Institut für Toxikologie und Pharmakologie, der Universität Würzburg, Versbacher Landstraße 9, 8700, Würzburg, Germany

    Dietrich Henschler

  3. Institut für Toxikologie, der Universität Mainz, Obere Zahlbacher Straße 67, 6500, Mainz, Germany

    Franz Oesch

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© 1987 Springer-Verlag

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Maronpot, R.R., Haseman, J.K., Boorman, G.A., Eustis, S.E., Rao, G.N., Huff, J.E. (1987). Liver Lesions in B6C3F1 Mice: The National Toxicology Program, Experience and Position. In: Chambers, P.L., Henschler, D., Oesch, F. (eds) Mouse Liver Tumors. Archives of Toxicology, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71617-1_2

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  • DOI: https://doi.org/10.1007/978-3-642-71617-1_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17124-9

  • Online ISBN: 978-3-642-71617-1

  • eBook Packages: Springer Book Archive

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