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The Mouse in Safety Evaluation

  • J. Doull
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 10)

Abstract

Several recent publications have reviewed the history, rationale and experience concerning the use of mice as a test species in oncogenicity bioassay programs. Conclusions from three of these publications will be discussed: The Report of the International Expert Advisory Committee on the Relevance of Mouse Liver Hepatoma to Human Carcinogenic Risk (from the Nutrition Foundation), the Report of the NTP Ad Hoc Panel on Chemical Carcinogenesis Testing and Evaluation (from the Board of Scientific Counselors of the National Toxicology Program), and Chemical Carcinogens: Review of the Science and its Associated Principles (from the Office of Science and Technology Policy). Using the recommendations from these and other groups regarding modification of the current testing protocols and alternative approaches to evaluating the adverse health effects of long-term, low-level exposure to environmental chemicals, an effort will be made to predict some future developments in this area of toxicology.

Key words

Nutrition Foundation Expert Panel ‘Ad hoc’ Panel National Toxicology Program Office of Science Technology Policy Chemical carcinogens 

Abbreviations

FDA

Food and Drug Administration

EPA

Environmental Protection Agency

NCI

National Cancer Institute

NCTR

National Center for Toxicologic Research

NTP

National Toxicology Program

NIEHS

National Institute of Environmental Health Science

OSHA

Occupational Safety and Health Administration

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References

  1. Chemical Carcinogens; A Review of the Science and Its Associated Principles, Office of Science and Technology Policy, Executive Office of the President (March, 1985 )Google Scholar
  2. The Relevance of Mouse Liver Hepatoma to Human Carcinogenic Risk, A Report of the International Expert Advisory Committee to the Nutrition Foundation (September, 1983)Google Scholar
  3. Report of the NTP Ad Hoc Panel on Chemical Carcinogenesis Testing and Evaluation, Board of Scientific Counselors, National Toxicology Program (August, 1984 )Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • J. Doull
    • 1
  1. 1.Department of Pharmacology, Toxicology and TherapeuticsUniversity of Kansas, Medical CenterKansas CityUSA

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