The Mouse in Safety Evaluation
Several recent publications have reviewed the history, rationale and experience concerning the use of mice as a test species in oncogenicity bioassay programs. Conclusions from three of these publications will be discussed: The Report of the International Expert Advisory Committee on the Relevance of Mouse Liver Hepatoma to Human Carcinogenic Risk (from the Nutrition Foundation), the Report of the NTP Ad Hoc Panel on Chemical Carcinogenesis Testing and Evaluation (from the Board of Scientific Counselors of the National Toxicology Program), and Chemical Carcinogens: Review of the Science and its Associated Principles (from the Office of Science and Technology Policy). Using the recommendations from these and other groups regarding modification of the current testing protocols and alternative approaches to evaluating the adverse health effects of long-term, low-level exposure to environmental chemicals, an effort will be made to predict some future developments in this area of toxicology.
Key wordsNutrition Foundation Expert Panel ‘Ad hoc’ Panel National Toxicology Program Office of Science Technology Policy Chemical carcinogens
Food and Drug Administration
Environmental Protection Agency
National Cancer Institute
National Center for Toxicologic Research
National Toxicology Program
National Institute of Environmental Health Science
Occupational Safety and Health Administration
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- Chemical Carcinogens; A Review of the Science and Its Associated Principles, Office of Science and Technology Policy, Executive Office of the President (March, 1985 )Google Scholar
- The Relevance of Mouse Liver Hepatoma to Human Carcinogenic Risk, A Report of the International Expert Advisory Committee to the Nutrition Foundation (September, 1983)Google Scholar
- Report of the NTP Ad Hoc Panel on Chemical Carcinogenesis Testing and Evaluation, Board of Scientific Counselors, National Toxicology Program (August, 1984 )Google Scholar