Abstract
Several recent publications have reviewed the history, rationale and experience concerning the use of mice as a test species in oncogenicity bioassay programs. Conclusions from three of these publications will be discussed: The Report of the International Expert Advisory Committee on the Relevance of Mouse Liver Hepatoma to Human Carcinogenic Risk (from the Nutrition Foundation), the Report of the NTP Ad Hoc Panel on Chemical Carcinogenesis Testing and Evaluation (from the Board of Scientific Counselors of the National Toxicology Program), and Chemical Carcinogens: Review of the Science and its Associated Principles (from the Office of Science and Technology Policy). Using the recommendations from these and other groups regarding modification of the current testing protocols and alternative approaches to evaluating the adverse health effects of long-term, low-level exposure to environmental chemicals, an effort will be made to predict some future developments in this area of toxicology.
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Abbreviations
- FDA:
-
Food and Drug Administration
- EPA:
-
Environmental Protection Agency
- NCI:
-
National Cancer Institute
- NCTR:
-
National Center for Toxicologic Research
- NTP:
-
National Toxicology Program
- NIEHS:
-
National Institute of Environmental Health Science
- OSHA:
-
Occupational Safety and Health Administration
References
Chemical Carcinogens; A Review of the Science and Its Associated Principles, Office of Science and Technology Policy, Executive Office of the President (March, 1985 )
The Relevance of Mouse Liver Hepatoma to Human Carcinogenic Risk, A Report of the International Expert Advisory Committee to the Nutrition Foundation (September, 1983)
Report of the NTP Ad Hoc Panel on Chemical Carcinogenesis Testing and Evaluation, Board of Scientific Counselors, National Toxicology Program (August, 1984 )
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© 1987 Springer-Verlag
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Doull, J. (1987). The Mouse in Safety Evaluation. In: Chambers, P.L., Henschler, D., Oesch, F. (eds) Mouse Liver Tumors. Archives of Toxicology, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71617-1_1
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DOI: https://doi.org/10.1007/978-3-642-71617-1_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-17124-9
Online ISBN: 978-3-642-71617-1
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