Skip to main content
SpringerLink
Log in

Development of Olfactory Epithelium in the Rat

  • Chapter
Ontogeny of Olfaction

Abstract

Several papers have been written on studies of the development of olfactory epithelium in vertebrates, including frogs (Klein and Graziadei 1983), chicks (e.g., Disse 1897; Van Campenhout 1937; Breipohl and Fernandez 1977; Breipohl and Ohyama 1981; Mendoza et al. 1982), mice (e.g., Smart 1971; Breipohl et al. 1973; Cuschieri and Bannister 1975a,b; Kerjaschki and Hörandner 1976; Kerjaschki 1977; Noda and Harada 1981), rats (Menco and Farbman 1985a,b; Farbman 1986), hamsters (Waterman and Meiler 1973; Taniguchi et al. 1982) and humans (O’Rahilly 1967; Bossy 1980; Pyatkina 1982; Nakashima et al. 1984). Most of these reports are primarily descriptive rather than analytical. In this chapter, we shall try to correlate descriptive morphological data on the ontogeny of the rat olfactory epithelium with some biochemical, immunological and physiological studies on early development and maturation

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allen WK, Akeson R (1985a) Identification of an olfactory receptor neuron subclass: Cellular and molecular analysis during development. Dev Biol 109: 393–401

    Article  PubMed  CAS  Google Scholar 

  • Allen WK, Akeson R (1985b) Identification of a cell surface glycoprotein family of olfactory receptor neurons with a monoclonal antibody. J Neuroscience 5: 284–296

    CAS  Google Scholar 

  • Barber PC, Lidsay RM (1982) Schwann cells of the olfactory nerves contain glial fibrillary acidic protein and resemble astrocytes. Neuroscience 7: 2687–2695

    Article  PubMed  CAS  Google Scholar 

  • Bossy Y (1980) Development of olfactory and related structures in staged human embryos. Anat Embryol 161: 225–236

    Article  PubMed  CAS  Google Scholar 

  • Breipohl W, Fernandez M (1977) Scanning electron microscopical investigations of olfactory epithelium in the chick embryo. Cell Tissue Res 183: 105–114

    Article  PubMed  CAS  Google Scholar 

  • Breipohl W, Ohyama M (1981) Comparative and developmental SEM studies on olfactory epithelia in vertebrates. (Biomedical aspects and speculations). Biomed Res (Suppl) 2: 437–448

    Google Scholar 

  • Breipohl W, Mestres P, Meiler K (1973) Licht- und elektronmikroskopische Befunde zur Differenzierung des Riechepithels des weissen Maus. Verh Anat Ges Jena 67: 443–449

    Google Scholar 

  • Campenhout E van (1937) Le dévellopement du système nerveux cranien chez le poulet. Arch Biol (Liege) 48: 611–666

    Google Scholar 

  • Chuah MI, Farbman Al, Menco BPhM (1985) Influence of olfactory bulb on dendritic knob density of rat olfactory receptor neurons in vitro. Brain Res 338: 259–266

    Article  PubMed  CAS  Google Scholar 

  • Couly GF, Le Douarin NM (1985) Mapping of the early neural primordium in quail-chick chimeras. I. Developmental relationships between placodes, facial ectoderm and prosencephalon. Devel Biol 110: 422–439

    Article  CAS  Google Scholar 

  • Cuschieri A, Bannister LH (1975a) The development of the olfactory mucosa in the mouse: light microscopy. J Anat 119: 277–286

    PubMed  CAS  Google Scholar 

  • Cuschieri A, Bannister LH (1975b) The development of the olfactory mucosa in the mouse: electron microscopy. J Anat 119:471–498

    PubMed  CAS  Google Scholar 

  • Disse J (1897) Die erste Entwicklung der Riechnerven. Anat Hefte 9: 257–300

    Google Scholar 

  • Farbman Al (1977) Differentiation of olfactory receptor cells in organ culture. Anat Rec 189: 187–200

    Article  PubMed  CAS  Google Scholar 

  • Farbman Al (1986) Prenatal development of mammalian olfactory receptor cells. Chem Senses (in press).

    Google Scholar 

  • Farbman Al, Margolis FL (1980) Olfactory marker protein during ontogeny: Immunohistochemical localization. Dev Biol 74: 205–215

    Article  PubMed  CAS  Google Scholar 

  • Farbman Al, Squinto LM (1985) Early development of olfactory receptor cell axons. Dev Brain Res 19: 205–213

    Article  Google Scholar 

  • Gesteland RC, Yancey RA, Farbman Al (1982) Development of olfactory receptor neuron selectivity in the rat fetus. Neuroscience 7: 3127–3136

    Article  PubMed  CAS  Google Scholar 

  • Gonzales F, Farbman Al, Gesteland RC (1985) Cell and expiant culture of olfactory chemoreceptor cells. J Neurosci Methods 14: 77–90

    Article  PubMed  CAS  Google Scholar 

  • Graziadei PPC, Monti Graziadei GA (1978) Continuous nerve cell renewal in the olfactory system. In: Jacobson M (ed) Development of sensory systems. Springer, Berlin, Heidelberg New York pp 55–83

    Chapter  Google Scholar 

  • Graziadei PPC, Monti Graziadei GA (1983) Regeneration in the olfactory system of vertebrates. Am J Otolaryngol 4: 228–233

    Article  PubMed  CAS  Google Scholar 

  • Hinds JW (1972) Early neuron differentiation in the mouse olfactory bulb. II. Electron microscopy. J Comp Neurol 146: 253–276

    Article  PubMed  CAS  Google Scholar 

  • Hinds JW, McNelly NA (1981) Aging in the rat olfactory system: correlation of changes in the olfactory epithelium and olfactory bulb. J Comp Neurol 203: 441–453

    Article  PubMed  CAS  Google Scholar 

  • Hinds JW, Hinds PL, McNelly NA (1984) An autoradiographic study of the mouse olfactory epithelium: evidence for long lived receptors. Anat Rec 210: 375–383

    Article  PubMed  CAS  Google Scholar 

  • Kerjaschki D (1977) Some freeze-etching data on the olfactory epithelium. In: Le Magnen J, Mac Leod P (eds) Olfaction and taste vol VI. Information Retrieval, London, Washington DC, pp 75–85

    Google Scholar 

  • Kerjaschki D, Hörandner H (1976) The development of mouse olfactory vesicles and their cell contacts: A freeze-etching study. J Ultrastruct Res 54: 420–444

    Article  PubMed  CAS  Google Scholar 

  • Klein SL, Graziadei PPC (1983) The differentiation of the olfactory placode in Xenopus laevis: A light and electron microscope study. J Comp Neurol 217: 17–30

    Article  PubMed  CAS  Google Scholar 

  • Margolis FL (1972) A brain protein unique to the olfactory bulb. Proc Natl Acad Sci USA 69: 1221–1224

    Article  PubMed  CAS  Google Scholar 

  • Margolis FL (1980) An olfactory neuropeptide. In: Barker JL, Smith T (eds) Role of peptides in neuronal function. Dekker, New York, pp 545–572

    Google Scholar 

  • Margolis FL (1982) Olfactory marker protein (OMP). Scand J Immunol (Suppl 9) 15: 181–199

    Article  CAS  Google Scholar 

  • Margolis FL, Grillo M, Kawano T, Farbman Al (1985) Carnosine synthesis in olfactory tissue during ontogeny: Effect of exogenous b-alanine. J Neurochem 44: 1459–1464

    Article  PubMed  CAS  Google Scholar 

  • Menco BPhM (1980) Qualitative and quantitative freeze-fracture studies on olfactory and nasal respiratory structures of frog, ox, rat, and dog. Cell Tissue Res 207: 183–209

    Article  PubMed  CAS  Google Scholar 

  • Menco BPhM (1983) The ultrastructure of olfactory and nasal respiratory epithelium surfaces. In: Reznik G, Stinson SF (eds) Nasal tumors in animals and man, vol I. Anatomy, physiology and epidemiology. CRS Press, Boca Raton, pp 45–102

    Google Scholar 

  • Menco BPhM (1984) Ciliated and microvillous structures of rat olfactory and nasal respiratory epithelia. A study using ultra-rapid cryo-fixation followed by freeze substitution or freeze-etching. Cell Tissue Res 235: 225–241

    Article  PubMed  CAS  Google Scholar 

  • Menco BPhM, Farbman Al (1985a) Genesis of cilia and microvilli of rat nasal epithelia during prenatal development. I. Olfactory epithelium, qualitative studies. J Cell Sci 78: 283–310

    PubMed  CAS  Google Scholar 

  • Menco BPhM, Farbman AI (1985b) Genesis of cilia and microvilli of rat nasal epithelia during prenatal development. II. Olfactory epithelium, a morphometric analysis. J Cell Sci 78: 311 – 336

    PubMed  CAS  Google Scholar 

  • Mendoza AS, Breipohl W, Miragall F (1982) Cell migration from the chick olfactory placode: a light and electron microscopic study. J Embryol Exp Morphol 69: 47–59

    PubMed  CAS  Google Scholar 

  • Miragall G, Monti Graziadei GA (1982) Experimental studies on the olfactory marker protein. II Appearance of the olfactory marker protein during differentiation of the olfactory sensory neurons of the mouse: An immunohistochemical and autoradiographic study. Brain Res 239: 245–250

    Article  PubMed  CAS  Google Scholar 

  • Mollicone R, Trojan J, Oriol R (1985) Appearance of H and B antigens in primary sensory cells of the rat olfactory apparatus and inner ear. Dev Brain Res 17: 275–279

    Article  Google Scholar 

  • Monti Graziadei GA, Stanley RS, Graziadei PPC (1980) The olfactory marker protein in the olfactory system of the mouse during development. Neuroscience 5: 1239–1252

    Article  Google Scholar 

  • Mori K, Fujita SC, Imamura K, Obata K (1985) Immunohistochemical study of subclasses of olfactory nerve fibers and their projections to the olfactory bulb in the rabbit. J Comp Neurol 242: 211–229

    Article  Google Scholar 

  • Nakashima T, Kimmelman CP, Snow JB Jr (1984) Structure of human fetal and adult olfactory neuroepithelium. Arch Otolaryngol 110: 641–646

    PubMed  CAS  Google Scholar 

  • Noda M, Harada Y (1981) Development of olfactory epithelium in the mouse: Scanning electron microscopy. Biomed Res (Suppl) 2: 449–454

    Google Scholar 

  • O’Rahilly R (1967) The early development of the nasal pit in staged human embryos. Anat Rec 157: 380

    Google Scholar 

  • Pyatkina GA (1982) Development of the olfactory epithelium in man. Z Mikrosk Anat Forsch, Leibzig 96: 361–372

    CAS  Google Scholar 

  • Romanoff AL (1960) The avian embryo, structural and functional development. MacMillan, New York, p 317

    Google Scholar 

  • Schwob JE, Gottlieb DI (1985) The primary olfactory projection has two chemically distinct zones. Neurosci Abstr 11: 970

    Google Scholar 

  • Schwob JE, Farber NB, Gottlieb DI (1986) Neurons of the olfactory epithelium in adult rats contain vimentin. J Neurosci 6: 208–217

    PubMed  CAS  Google Scholar 

  • Scifert K (1970) Die Ultrastruktur des Riechepithels beim Makrosmatiker. Eine elektronenmikroskopische Untersuchung. In: Bargmann W, Doerr W (eds) Normale und pathologische Anatomie. Monographien in zwangloser Folge. Thieme, Stuttgart, pp 1–99

    Google Scholar 

  • Smart IHM (1971) Location and orientation of mitotic figures in the developing mouse olfactory epithelium. J Anat 109: 243–251

    PubMed  CAS  Google Scholar 

  • Sorokin SP (1968) Reconstructions of centriole formation and ciliogenesis in mammalian lungs. J Cell Sci 3: 207–230

    PubMed  CAS  Google Scholar 

  • Taniguchi K, Taniguchi K, Mochizoki K (1982) Comparative developmental studies on the fine structure of the vomeronasal sensory and the olfactory epithelia in the golden hamster. Jpn J Vet Sci 44: 881–890

    Article  CAS  Google Scholar 

  • Tucker RW, Pardee AB (1982) Primary cilia and their role in the regulation of DNA replication and mitosis. In: Nicolini C (ed) Cell growth. Plenum Press, New York, pp 365–376

    Google Scholar 

  • Vidic B, Greditzer HG, Litchy WJ (1972) The structure and prenatal morphogenesis of the nasal septum in the rat. J Morphol 137: 131–148

    Article  PubMed  CAS  Google Scholar 

  • Waterman RE, Meiler SM (1973) Nasal pit formation in the hamster: A transmission and scanning electron microscopic study. Dev Biol 34: 255–266

    Article  PubMed  CAS  Google Scholar 

  • Wheatley DN (1982) The centriole: a central enigma of cell biology. Elsevier Biomedical Press, Amsterdam New York Oxford

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, 60201, USA

    A. I. Farbman & B. Ph. M. Menco

Authors
  1. A. I. Farbman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Ph. M. Menco
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Anatomy, University of Queensland, St. Lucia/Brisbane, Australia, 4067

    Winrich Breipohl

  2. Institut für Biologie III, Universität Tübingen, 7400, Tübingen, Germany

    Raimund Apfelbach

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Farbman, A.I., Menco, B.P.M. (1986). Development of Olfactory Epithelium in the Rat. In: Breipohl, W., Apfelbach, R. (eds) Ontogeny of Olfaction. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71576-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71576-1_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71578-5

  • Online ISBN: 978-3-642-71576-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation