Abstract
The Abelson murine leukemia virus (A-MuLV) is a rapidly transforming, defective retrovirus that induces pre-B cell tumors in susceptible mice (Abelson and Rabstein 1970, Scher and Siegler 1974, Rosenberg and Baltimore 1976, Risser et al 1978). It encodes the v-abl pl60 transforming protein, a tyrosine-kinase viral oncogene product. The v-abl oncogene was formed by the fusion of the Moloney MuLV (M-MuLV) gag gene with cellular c-abl sequences (Reynolds et al 1978, Witte et al 1978). The A-MuLV genome is a genetic recombinant of M- MuLV with the c-abl proto-oncogene (Wang et al 1984), and thus expression of the v-abl gene is controlled by the LTR derived from M-MuLV. Although M-MuLV induces predominantly T-cell tumors, A-MuLV induces pre-B cell tumors. The tissue tropism of M-MuLV is controlled by the LTR (Chatis et al 1983).
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References
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© 1986 Springer-Verlag Berlin · Heidelberg
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Green, P.L., Holland, G.D., Kaehler, D., McKearn, J., McCubrey, J., Risser, R. (1986). Determinants of Abelson Murine Leukemia Virus Pathogenesis. In: Melchers, F., Potter, M. (eds) Mechanisms in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71562-4_9
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DOI: https://doi.org/10.1007/978-3-642-71562-4_9
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