Determinants of Abelson Murine Leukemia Virus Pathogenesis

  • Patrick L. Green
  • Gina D. Holland
  • Donal Kaehler
  • John McKearn
  • James McCubrey
  • Rex Risser
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

The Abelson murine leukemia virus (A-MuLV) is a rapidly transforming, defective retrovirus that induces pre-B cell tumors in susceptible mice (Abelson and Rabstein 1970, Scher and Siegler 1974, Rosenberg and Baltimore 1976, Risser et al 1978). It encodes the v-abl pl60 transforming protein, a tyrosine-kinase viral oncogene product. The v-abl oncogene was formed by the fusion of the Moloney MuLV (M-MuLV) gag gene with cellular c-abl sequences (Reynolds et al 1978, Witte et al 1978). The A-MuLV genome is a genetic recombinant of M- MuLV with the c-abl proto-oncogene (Wang et al 1984), and thus expression of the v-abl gene is controlled by the LTR derived from M-MuLV. Although M-MuLV induces predominantly T-cell tumors, A-MuLV induces pre-B cell tumors. The tissue tropism of M-MuLV is controlled by the LTR (Chatis et al 1983).

Keywords

Lymphoma Leukemia Agarose Peri Mast 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • Patrick L. Green
    • 1
  • Gina D. Holland
    • 1
  • Donal Kaehler
    • 1
  • John McKearn
    • 2
  • James McCubrey
    • 2
  • Rex Risser
    • 1
  1. 1.McArdle Laboratory for Cancer ResearchUniversity of WisconsinMadisonUSA
  2. 2.E. I. duPont deNemours & Co.Glenolden LaboratoryGlenoldenUSA

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