Rapid Induction of Plasmacytomas in Mice by Pristane and a Murine Recombinant Retrovirus Containing an Avian v-myc and a Defective raf Oncogene
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Plasma cell tumors can be induced in genetically susceptible BALB/cAn mice by the intraperitoneal injection of various kinds of mineral (paraffin) oils or available components of these oils. Currently, the most widely used agent is pristane 2,6,10,14 tetramethy1pentadecane. The incidence of plasma cell tumors obtained in BALB/cAn mice varies according to the dose of pristane. The highest incidence of plasmacytomas occurs when mice are given three 0.5 ml i. p. injections of pristane, spaced 2 months apart (Potter and Wax 1983). Approximately 60% of the mice treated with this regimen develop plasmacytomas with a minimal latent period of 120 days and a mean latent period of 210–220 days. In contrast, when mice are given a single injection of 0.5 ml pristane i. p., only 25–30% develop plasmacytomas. The minimal latent period is 140 days and the mean latent period ca. 215 days.
KeywordsMyeloid Tumor Plasma Cell Tumor Fixed Tissue Section 3Frederick Cancer Research Pristane Injection
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