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Rapid Induction of Plasmacytomas in Mice by Pristane and a Murine Recombinant Retrovirus Containing an Avian v-myc and a Defective raf Oncogene

  • M. Potter
  • J. Wax
  • E. Mushinski
  • S. Brust
  • M. Babonits
  • F. Wiener
  • J. F. Mushinski
  • D. Mezebish
  • R. Skurla
  • U. Rapp
  • H. C. MorseIII
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

Plasma cell tumors can be induced in genetically susceptible BALB/cAn mice by the intraperitoneal injection of various kinds of mineral (paraffin) oils or available components of these oils. Currently, the most widely used agent is pristane 2,6,10,14 tetramethy1pentadecane. The incidence of plasma cell tumors obtained in BALB/cAn mice varies according to the dose of pristane. The highest incidence of plasmacytomas occurs when mice are given three 0.5 ml i. p. injections of pristane, spaced 2 months apart (Potter and Wax 1983). Approximately 60% of the mice treated with this regimen develop plasmacytomas with a minimal latent period of 120 days and a mean latent period of 210–220 days. In contrast, when mice are given a single injection of 0.5 ml pristane i. p., only 25–30% develop plasmacytomas. The minimal latent period is 140 days and the mean latent period ca. 215 days.

Keywords

Myeloid Tumor Plasma Cell Tumor Fixed Tissue Section 3Frederick Cancer Research Pristane Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • M. Potter
    • 1
    • 2
  • J. Wax
    • 1
    • 2
  • E. Mushinski
    • 1
    • 2
  • S. Brust
    • 1
    • 2
  • M. Babonits
    • 1
    • 3
  • F. Wiener
    • 1
    • 3
  • J. F. Mushinski
    • 1
    • 2
  • D. Mezebish
    • 1
    • 2
  • R. Skurla
    • 1
    • 2
  • U. Rapp
    • 1
    • 4
  • H. C. MorseIII
    • 5
  1. 1.Laboratory of GeneticsNational Cancer Institute, National Institutes of HealthBethesdaUSA
  2. 2.Hazleton LaboratoriesRockvilleUSA
  3. 3.Karolinska InstituteStockholmSweden
  4. 4.Frederick Cancer Research CenterFrederickUSA
  5. 5.National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA

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