Mutations which Stabilize myc Transcripts and Enhance myc Transcription in Two Mouse Plasmacytomas
We previously reported preliminary findings concerning two mouse plasmacytomas, TEPC 1165 and TEPC 2027 which make abundant myc transcripts of 3.9 and 4.0 kb, respectively. A Northern blot of poly(A)+ RNAs from TEPC 1165 and TEPC 2027 probed with various portions of the myc gene showed that the first intervening sequence (IVS-I) ends up in mature myc mRNAs of both tumors (Mushinski 1985). All three myc gene exons are present as well.
KeywordsSplice Donor Site Heavy Chain Constant Region Tissue Culture Line Globin Transcript Linearize Plasmid DNAs
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