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Altered c-myc RNA Metabolism in Burkitt’s Lymphomas and Mouse Plasmacytomas

  • M. Piechaczyk
  • A. Bonnieu
  • D. Eick
  • E. Remmers
  • J-Q. Yang
  • K. Marcu
  • Ph. Jeanteur
  • J-M Blanchard
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Summary

Exon 1 deleted c-myc RNAs found in some mouse plasma cell tumors (Piechaczyk et al., 1985) and Burkitt’s lymphomas (Eick et al., 1985) are more stable than their normal counterparts in control cells. In this paper we extend our original observations to other B cell and we prove that the structural modification of c-myc RNA is responsible for its stabilization. However, we also show that exon 1 by itself does not account for the extreme instability of normal c-myc RNAs. Finally our results suggest that abnormal c-myc transcripts, while always stabilized in the cytoplasm, may sometimes be more actively degraded in the nucleus than normal ones in reference cell lines.

Keywords

Plasma Cell Tumor Cryptic Promoter Immunoglobulin Locus Reference Cell Line RNAse Mapping 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • M. Piechaczyk
    • 1
  • A. Bonnieu
    • 1
  • D. Eick
    • 2
  • E. Remmers
    • 3
  • J-Q. Yang
    • 3
  • K. Marcu
    • 3
  • Ph. Jeanteur
    • 1
  • J-M Blanchard
    • 1
  1. 1.Laboratoire de Génétique MoléculaireMontpellier CedexFrance
  2. 2.Institüt fur VirologieZentrum für Hygiene der Universität FreiburgFreiburgGermany
  3. 3.Dpt of biochemistrySUNY at Stony BrookStony BrookUSA

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