Activation of Proto-oncogene Expression by Growth Regulatory Signals

  • W. Ran
  • M. Dean
  • R. A. Levine
  • J. Campisi
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)


c-myc and c-fos are proto-oncogenes that encode unstable proteins localized in the cell nucleus (Curran et al. 1984; Kruijer et al. 1984; Muller er al. 1984; Eisenman et al. 1984; Rabbitts et al. 1985). Both proto-oncogenes, but especially c-myc, have been implicated in the establishment or progression of a variety of tumors. In many lymphoid tumors, the c-myc gene has undergone structural alterations in 5’noncoding sequences that are believed important for normal regulation (Stanton et al. 1983; Leder et al. 1983). By contrast, certain tumorigenic fibroblasts have lost the ability to regulate c-myc expression properly, apparently because of mutation(s) outside the c-myc gene (Campisi et al. 1984; Dean, Vande Woude, Campisi, in preparation).


Cholera Toxin Subconfluent Cell Growth Regulatory Signal Cell Surface Signal Transduction Frederick Cancer Research Facility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • W. Ran
    • 1
  • M. Dean
    • 2
  • R. A. Levine
    • 1
  • J. Campisi
    • 1
  1. 1.Department of BiochemistryBoston University Medical SchoolBostonUSA
  2. 2.Frederick Cancer Research FacilityFrederickUSA

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