Activation of Proto-oncogene Expression by Growth Regulatory Signals
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c-myc and c-fos are proto-oncogenes that encode unstable proteins localized in the cell nucleus (Curran et al. 1984; Kruijer et al. 1984; Muller er al. 1984; Eisenman et al. 1984; Rabbitts et al. 1985). Both proto-oncogenes, but especially c-myc, have been implicated in the establishment or progression of a variety of tumors. In many lymphoid tumors, the c-myc gene has undergone structural alterations in 5’noncoding sequences that are believed important for normal regulation (Stanton et al. 1983; Leder et al. 1983). By contrast, certain tumorigenic fibroblasts have lost the ability to regulate c-myc expression properly, apparently because of mutation(s) outside the c-myc gene (Campisi et al. 1984; Dean, Vande Woude, Campisi, in preparation).
KeywordsCholera Toxin Subconfluent Cell Growth Regulatory Signal Cell Surface Signal Transduction Frederick Cancer Research Facility
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