Abstract
c-myc and c-fos are proto-oncogenes that encode unstable proteins localized in the cell nucleus (Curran et al. 1984; Kruijer et al. 1984; Muller er al. 1984; Eisenman et al. 1984; Rabbitts et al. 1985). Both proto-oncogenes, but especially c-myc, have been implicated in the establishment or progression of a variety of tumors. In many lymphoid tumors, the c-myc gene has undergone structural alterations in 5’noncoding sequences that are believed important for normal regulation (Stanton et al. 1983; Leder et al. 1983). By contrast, certain tumorigenic fibroblasts have lost the ability to regulate c-myc expression properly, apparently because of mutation(s) outside the c-myc gene (Campisi et al. 1984; Dean, Vande Woude, Campisi, in preparation).
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© 1986 Springer-Verlag Berlin · Heidelberg
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Ran, W., Dean, M., Levine, R.A., Campisi, J. (1986). Activation of Proto-oncogene Expression by Growth Regulatory Signals. In: Melchers, F., Potter, M. (eds) Mechanisms in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71562-4_46
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DOI: https://doi.org/10.1007/978-3-642-71562-4_46
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