Differential Expression of N-myc, c-myc and c-src Proto-oncogenes During the Course of Induced Differentiation of Murine Embryonal Carcinoma Cells

  • J. Sumegi
  • T. Sejersen
  • H. Björklund
  • G. Klein
  • N. R. Ringertz
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)


Proto-oncogenes the cellular homologues of retroviral oncogenes, appear to be normal cellular genes presumed to play a role in normal cellular processes like growth control and cellular differentiation. Their role in controlling cellular growth is strongly supported by the findings that several proto-oncogenes code for proteins closely related or identical to growth factors or growth factor receptors. It has been also found that the expression of proto-oncogenes c-myc and c-myb is diminished and the expression of c-fos is induced during differentiation of HL60 and U-937 cells (Mitchell 1985).


Retinoic Acid Embryonal Carcinoma Cell Visceral Endoderm Human Small Cell Lung Cancer Embryonal Carcinoma Cell Line 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • J. Sumegi
    • 1
  • T. Sejersen
    • 2
  • H. Björklund
    • 3
  • G. Klein
    • 1
  • N. R. Ringertz
    • 2
  1. 1.Department of Tumor BiologyMedical Nobel InstituteStockholmSweden
  2. 2.Department of Medical Cell GeneticsMedical Nobel InstituteStockholmSweden
  3. 3.Department of HistologyKarolinska InstituteStockholmSweden

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