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Differential Expression of N-myc, c-myc and c-src Proto-oncogenes During the Course of Induced Differentiation of Murine Embryonal Carcinoma Cells

  • J. Sumegi
  • T. Sejersen
  • H. Björklund
  • G. Klein
  • N. R. Ringertz
Conference paper
  • 48 Downloads
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

Proto-oncogenes the cellular homologues of retroviral oncogenes, appear to be normal cellular genes presumed to play a role in normal cellular processes like growth control and cellular differentiation. Their role in controlling cellular growth is strongly supported by the findings that several proto-oncogenes code for proteins closely related or identical to growth factors or growth factor receptors. It has been also found that the expression of proto-oncogenes c-myc and c-myb is diminished and the expression of c-fos is induced during differentiation of HL60 and U-937 cells (Mitchell 1985).

Keywords

Retinoic Acid Embryonal Carcinoma Cell Visceral Endoderm Human Small Cell Lung Cancer Embryonal Carcinoma Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • J. Sumegi
    • 1
  • T. Sejersen
    • 2
  • H. Björklund
    • 3
  • G. Klein
    • 1
  • N. R. Ringertz
    • 2
  1. 1.Department of Tumor BiologyMedical Nobel InstituteStockholmSweden
  2. 2.Department of Medical Cell GeneticsMedical Nobel InstituteStockholmSweden
  3. 3.Department of HistologyKarolinska InstituteStockholmSweden

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