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Regulation of c-myc mRNA and Protein Levels During Activation of Normal Human B Cells

  • Erlend B. Smeland
  • Tore Godal
  • Klaus Beiske
  • Rosemary Watt
  • Susan Pfeifer-Ohlsson
  • Rolf Ohlsson
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

The myc oncogene has been implicated in the control of cellular proliferation in both normal and neoplastic cells. Recently, several cell lines have been shown to express c-myc mRNA and protein throughout the cell cycle (Thompson et al 1985; Hann et al 1985; Rabbitts et al 1985). However, in several cell systems triggering of quiescent cells into G1 is accompanied by a marked burst of c-myc mRNA, peaking a few hours after stimulation (Kelly et al 1983; Goustin et al 1985; Smeland et al 1985a). This has focused on a possible function for the c-myc product during the induction of competence to respond to progression growth factors acting in G1. This theory finds support in studies on fibroblast cell lines, where experimental manipulation of c-myc levels was related to cell cycle progression (Armelin et al 1984; Kaczmarek et al 1985). In both cases the increased myc levels provoked an increased sensitivity to the action of progression factors.

Keywords

Norwegian Radium Hospital Cytospin Specimen Marked Burst 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • Erlend B. Smeland
    • 1
    • 2
  • Tore Godal
    • 1
    • 2
  • Klaus Beiske
    • 1
    • 2
  • Rosemary Watt
    • 3
  • Susan Pfeifer-Ohlsson
    • 1
    • 2
    • 4
  • Rolf Ohlsson
    • 1
    • 2
    • 4
  1. 1.Laboratory of ImmunologyDepartment of Pathology and the Norwegian Cancer SocietyOslo 3Norway
  2. 2.The Norwegian Radium HospitalOslo 3Norway
  3. 3.Molecular Oncology GroupSmith Kline and French LaboratoriesPhiladelphiaUSA
  4. 4.Department of OncologyUniversity of UmeåUmeåSweden

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