Regulation of c-myc mRNA and Protein Levels During Activation of Normal Human B Cells
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The myc oncogene has been implicated in the control of cellular proliferation in both normal and neoplastic cells. Recently, several cell lines have been shown to express c-myc mRNA and protein throughout the cell cycle (Thompson et al 1985; Hann et al 1985; Rabbitts et al 1985). However, in several cell systems triggering of quiescent cells into G1 is accompanied by a marked burst of c-myc mRNA, peaking a few hours after stimulation (Kelly et al 1983; Goustin et al 1985; Smeland et al 1985a). This has focused on a possible function for the c-myc product during the induction of competence to respond to progression growth factors acting in G1. This theory finds support in studies on fibroblast cell lines, where experimental manipulation of c-myc levels was related to cell cycle progression (Armelin et al 1984; Kaczmarek et al 1985). In both cases the increased myc levels provoked an increased sensitivity to the action of progression factors.
KeywordsNorwegian Radium Hospital Cytospin Specimen Marked Burst
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