Myc Expression in vivo During Human Embryogenesis

  • Rolf I. Ohlsson
  • Susan Pfeifer-Ohlsson
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

The postulated involvement of the myc oncogene in human neoplasia (Klein 1983, Adams 1985, Little 1984) lends considerable support from work on the retroviral myc oncogene. Thus, the v-myc oncogene promotes, directly or indirectly, immortalization of target cells, evasion from normal regulatory growth controls in addition to tumorigenic behaviour of transformed cells injected into syngeneic animals (Rapp 1985, Blasi 1985, Pfeifer-Ohlsson 1983).

Keywords

Sarcoma Thymidine Kelly 

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References

  1. Anzano MA, Roberts AB, Sporn M (1986) Anchorage-independent growth of primary rat embryo cells is induced by platelet-derived growth factor and inhibited by type-beta transforming growth factor J Cell Phys 126: 312–318Google Scholar
  2. Adams JM, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, Cory S, Palmiter RD, Brinster RL (1985) The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice Nature 318: 533–538Google Scholar
  3. Blasi E, Mathieson BJ, Varesio L, Cleveland JL, Borchert PA, Rapp UR (1985) Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retro virus Nature 318: 667–670Google Scholar
  4. Campisi J, Gray HE, Pardee AB, Dean M, Sonenshein G (1984) Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation Cell 36: 241–247PubMedGoogle Scholar
  5. Doolittle RF, Hunkapiller MW, Hood LE, Devare SG, Robbins KL, Aaronson SA, Antoniades HN (1983) Simian sarcoma virus one gene, v-sis, is derived from the gene (or genes) encoding the platelet-derived growth factor Science 221: 275–277Google Scholar
  6. Gerbie AB, Hathway HH, Brewer JI (1968) Autoradiographic analysisGoogle Scholar
  7. of normal trophoblast proliferation Am J Obst Gyn 100:640–650Google Scholar
  8. Goustin AS, Betsholtz C, Pfeifer-Ohlsson SB, Persson H, Rydnert J, Bywater M, Holmgren G, Heldin C-H, Westermark B, Ohlsson R (1985) Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth Cell 41: 301–312Google Scholar
  9. Hamilton WJ, Hamilton DV (1977) Development of the human placenta, Scientific foundations of obstretics and gynecology. Heinemann, LondonGoogle Scholar
  10. Hann SR, Thompson CB, Eisenman RN (1985) C-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells Nature 314: 366–369Google Scholar
  11. Kelly K, Cochran BH, Stiles CD, Leder P (1983) Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor Cell 35: 603–610Google Scholar
  12. Klein G (1983) Specific chromosomal variations and the genesis of B cell-derived tumours in mice and men Cell 32: 771–778Google Scholar
  13. Stanton, L, Schwab, M, Bishop, JM (1986) Nucleotide sequence of the human N-myc gene Proc Nat Acad Sci USA 83, 1772–1776Google Scholar
  14. Little CD, Nau MN, Carney DN, Gazdar AF, Minna JD (1983) Amplification and expression of the c-myc oncogene in human lung cancer cell lines Nature 306: 194–197Google Scholar
  15. Nau MN, Brooks BJ, Battey J, Sausville E, Gazdar AF, Kirsch IR, McBride OW, Bertness V, Hollis GF, Minna JD (1985) L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer Nature 318: 69–73Google Scholar
  16. Pfeifer-Ohlsson (1984) OKlO-transformed cell lines: viral component generation and tumorigenecity Intervir. 21: 121–133Google Scholar
  17. Pfeifer-Ohlsson SB, Goustin AS, Rydnert J, Wahlstrom T, Bjersing L, Stehelin D, Ohlsson R (1984) Spatial and temporal pattern of cellular myc oncogene in developing human placenta: implica tions for embryonic proliferation Cell 38: 585–596Google Scholar
  18. Pfeifer-Ohlsson SB, Rydnert J, Goustin AS, Larsson E, Betsholtz C, Ohlsson R. Cell-type-specific pattern of myc protooncogene expression in developing human embryos Proc Nat Acad Sci USA 82: 5050–5054Google Scholar
  19. Rapp UR, Cleveland JL, Brightman K, Scott A, Ihle JN (1985) Abrogration of IL-3 and IL-2 dependence by recombinant retrovi ruses expressing v-myc oncogenes Nature 317, 434–437Google Scholar
  20. Smeland E, Godal T, Ruud E, Beiske K, Funderud S, Clark E, Pfeifer-Ohlsson S, Ohlsson R (1985) The specific induction of myc protooncogene expression in human B cells is not a sufficient event for acquisition of competence to proliferate Proc Nat Acad Sci USA 82: 6255–6259Google Scholar
  21. Sporn M, Todaro G (1980) Autocrine secretion and malignant transformation of cells N Engl J Med 303: 878–880Google Scholar
  22. Thompson CB, Challoner PB, Neiman PE, Groudine M (1985) Levels of c-myc oncogene mRNA are invariant throughout the cell cycle Nature 314: 363–366Google Scholar
  23. Watt RA, Shatzman AR, Rosenberg M (1985) Mol Cell Biol 5: 448–456PubMedGoogle Scholar
  24. Schwab, M, Varmus, HE, and Bishop, JM (1985) Nature 316, 160–162PubMedCrossRefGoogle Scholar
  25. Zimmerman KA, Yancopolous GD, Collum RG, Smith RK, Kohl NE, Denis KA, Nau MM, Witte ON, Toran-Allerand D, Gee CE, Minna JD, Alt F (1986) Differential expression of myc family genes during murine development Nature 319: 780–783Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • Rolf I. Ohlsson
    • 1
  • Susan Pfeifer-Ohlsson
    • 1
  1. 1.Department of OncologyUniversity of UmeaUmeaSweden

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