EBV-Activation of Human B-Lymphocytes
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The Epstein-Barr virus (EBV) is a human herpes virus originally discovered in Burkitt lymphoma cell lines. The virus was found to specifically infect a sub-population of B-lymphocytes. In vitro infected B-cells are transformed into immortalized but non-tumorigenic lymphoblastoid cell lines (LCL). The cell lines maintain the genome in a latent form with only limited parts of the genome expressed and none or very little virus is produced (Menezes 1976). Some of the latently transcribed EBV genes code for different components of the EBV nuclear antigens (EBNA) expressed in the cell nucleus of all EBV-carrying cells (Reedman 1973).
KeywordsGerminal Center Lymphoblastoid Cell Line Germinal Center Cell Burkitt Lymphoma Cell Line Cord Blood Lymphocyte
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