Structure and Expression of Translocated c-myc Oncogenes: Specific Differences in Endemic, Sporadic and AIDS-Associated Forms of Burkitt Lymphomas
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Burkitt lymphomas (BL) are characterized by reciprocal chromosomal translocations which involve the c-myc oncogene locus on chromosome 8 and immunoglobulin (Ig) loci on either chromosome 2, 14 or 22 (Dalla-Favera et al. 1982, 1983; Taub et al. 1982; Leder et al. 1983; Croce et al. 1985). The consistent occurrence of these specific recombination events in BL and the presence of analogous recombinations involving c-myc in similar tumors in other species (Sheng-Ong 1982), suggests that the c-myc gene plays a role in the pathogenesis of BL. Despite their remarkable similarity at the cytogenetic level, these translocation events are extremely heterogeneous at the molecular level. In this study we report that chromosomal breakpoints and structural alterations of the c-myc locus differ in different subtypes of Burkitt lymphomas, namely endemic, sporadic BL and AIDS-associated undifferentiated B-cell lymphomas (AIDS-UBL). Chromosomal translocation is also associated with different levels of c-myc expression, and these levels directly correlate with the clonogenic and in vivo tumorigenic properties of BL cells.
KeywordsBurkitt Lymphoma Chromosomal Breakpoint Small Cell Lung Carcinoma Cell Mouse Plasmacytomas
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