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Structure and Expression of Translocated c-myc Oncogenes: Specific Differences in Endemic, Sporadic and AIDS-Associated Forms of Burkitt Lymphomas

  • Luisa Lanfrancone
  • Pier-Giuseppe Pelicci
  • Riccardo Dalla-Favera
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

Burkitt lymphomas (BL) are characterized by reciprocal chromosomal translocations which involve the c-myc oncogene locus on chromosome 8 and immunoglobulin (Ig) loci on either chromosome 2, 14 or 22 (Dalla-Favera et al. 1982, 1983; Taub et al. 1982; Leder et al. 1983; Croce et al. 1985). The consistent occurrence of these specific recombination events in BL and the presence of analogous recombinations involving c-myc in similar tumors in other species (Sheng-Ong 1982), suggests that the c-myc gene plays a role in the pathogenesis of BL. Despite their remarkable similarity at the cytogenetic level, these translocation events are extremely heterogeneous at the molecular level. In this study we report that chromosomal breakpoints and structural alterations of the c-myc locus differ in different subtypes of Burkitt lymphomas, namely endemic, sporadic BL and AIDS-associated undifferentiated B-cell lymphomas (AIDS-UBL). Chromosomal translocation is also associated with different levels of c-myc expression, and these levels directly correlate with the clonogenic and in vivo tumorigenic properties of BL cells.

Keywords

Burkitt Lymphoma Chromosomal Breakpoint Small Cell Lung Carcinoma Cell Mouse Plasmacytomas 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • Luisa Lanfrancone
    • 1
  • Pier-Giuseppe Pelicci
    • 1
  • Riccardo Dalla-Favera
    • 1
  1. 1.Dept. of Pathology and Kaplan Cancer CenterNew York University School of MedicineNew YorkUSA

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