Epstein-Barr Virus Gene Expression During Primary B-Lymphocyte Infection, in Transformed and Burkitt Lymphoma-Derived Cell Lines

  • I. Ernberg
  • B. Kallin
  • J. Dillner
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)


Epstein-Barr virus (EBV) infection of resting human B-lymphocytes results in the establishment of transformed, continuously growing, virus genome carrying lymphoblastoid cell lines (LCL). This consequence of the virus infection is dependent on virus gene expression, as ultraviolet irradiation of EBV decreases the efficiency of transformation in a dose dependent manner. The early steps of the EBV infection shows many phenotypical parallels to B-lymphocyte activation obtained by mitogens and lymphokines in appropriate combinations. Thus EBV-induced B-lymphocyte activation defined as the first cell cycles after infection is one model from which conclusions can be made about signals involved in triggering of human B-lymphocytes. The expression and function of the virus coded proteins, which are present after EBV infection will be particularly usefool tools in providing knowledge about the significance of various steps in the B-lymphocyte activation. Some of these proteins may complement or replace cellular proteins that function in the physiologic, antigen induced lymphocyte activation. The cellular proteins cannot be identified so easily as those coded for by the virus, due to the availability of specific antibodies against the viral proteins.


Lymphoblastoid Cell Line Virus Gene Expression Tumor Derive Cell Line Virus Nuclear Antigen Human Antiserum 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • I. Ernberg
    • 1
  • B. Kallin
    • 1
  • J. Dillner
    • 1
  1. 1.Department of Tumor BiologyKarolinska InstituteStockholmSweden

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