Induction of fgr Proto-oncogene mRNA in B Lymphocytes as a Consequence of Epstein-Barr Virus Infection

  • M. S. C. Cheah
  • T. J. Ley
  • S. R. Tronick
  • K. C. Robbins
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)


The discovery that the v-sis oncogene was derived from a normal growth factor gene represented the first link between a transforming gene and a known cellular function. More recently, two additional retrovirus onc genes have been shown to be altered versions of normal cellular genes encoding cell surface receptors for other growth factors, namely epidermal growth factor (EGF) (Downward et al., 1984; Ullrich et al., 1984) and very likely colony stimulating factor-1 (CSF-l) (Sherr et al., 1985).


Lymphoma Cell Line RAMOS Cell Normal Human Peripheral Blood Normal Human Lung Tissue Dhfr mRNA 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • M. S. C. Cheah
    • 1
    • 2
  • T. J. Ley
    • 1
    • 2
  • S. R. Tronick
    • 1
    • 2
  • K. C. Robbins
    • 1
    • 2
  1. 1.Laboratory of Cellular and Molecular BiologyNational Cancer InstituteBethesdaUSA
  2. 2.Clinical Hematology BranchNational Heart, Lung and Blood InstituteBethesdaUSA

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