Inbred Strain Differences Influence the Focal Proliferation of Plasma Cells in Pristane Induced Oil Granuloma

  • M. Potter
  • J. S. Wax
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)


Plasmacytomas are inducible in a few genetically susceptible strains of mice (BALB/cAn, NZB) by the intraperitoneal injection of mineral oils (see Potter 1984 for refs). However, many other strains are resistant to plasma cell tumor formation (Potter et al. 1975, 1984; Potter and Wax 1981). Pristane (2, 6, 10, 14 tetramethy1pentadecane), a component of many mineral oils, also has a biogenic origin being produced by marine copepods from phytane. Pristane, like most of the components of mineral or paraffin oil, is not metabolized and its role as a piasmacytomagenic agent is not direct. When pristane and mineral oils are injected i. p., they induce the formation of a reactive tissue that forms on peritoneal surfaces, called oil granuloma (06) (Potter and MacCardle 1964). The 0G results from the phagocytosis of oil droplets by cells in the macrophage and myeloid series. A variety of configurations of oil droplets are seen in this tissue ranging from intracellular oil droplets to cystic structures onto which a variable number of macrophages and or neutrophils adhere. The oil laden phagocytes and the larger droplets surrounded by phagocytes adhere to mesothelial surfaces and become vascularized from underlying blood vessels and covered with mesothelium. The organized 0G is invaded by other types of inflammatory cells and lymphocytes. Plasma cells can be found scattered throughout. 0G formation begins very soon after the injection of pristane and is well developed by day 20.


Plasma Cell Focal Plasma Multiple Focus Marine Copepod Focal Proliferation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Emerit I, Cerutti PA (1982) Tumor promoter phorbol-12-myristate- 13-acetate induces a clastogenic factor in human lymphocytes. Proc Natl Acad Sci USA 79: 7509–7513PubMedCrossRefGoogle Scholar
  2. Ohno S, Babonits M, Wiener F, Spira J, Klein G, Potter M (1979) Non-random chromosome changes involving the Ig gene-carrying chromosomes 12 and 6 in pristane-induced mouse plasmacytomas. Cell 18: 1 001–1007CrossRefGoogle Scholar
  3. Ohno S, Migita S, Wiener F, Babonits M, Klein G, Mushinski JF, Potter M (1984) Chromosomal translocations activating myc sequences and transduction of v-abl are crtical events in the rapid induction of plasmacytomas by pristane and Abelson virus. J Exp Med 159: 1762–1777PubMedCrossRefGoogle Scholar
  4. Potter M (1984) Genetics of susceptibility to plasmacytoma development in BALB/c mice. Cancer Surveys 3: 247–264Google Scholar
  5. Potter M, Hartley JW, Wax JS, Gallahan D (1984) Effect of MuLV- related genes on piasmacytomagenesis in BALB/c mice. J Exp Med 160: 435–440PubMedCrossRefGoogle Scholar
  6. Potter M, MacCardle RC (1964) Histology of developing plasma cell neoplasia induced by mineral oil in BALB/c mice. J Natl Cancer Inst 33: 497–515PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • M. Potter
    • 1
  • J. S. Wax
    • 2
  1. 1.Laboratory of GeneticsNational Cancer Institute, National Institutes of HealthBethesdaUSA
  2. 2.Hazleton LaboratoriesRockvilleUSA

Personalised recommendations