Abstract
In both Burkitt’s lymphomas and murine plasmacytomas there are specific disease-associated chromosomal translocations that bring into contiguity one of the immunoglobulin gene loci with the c-myc proto-oncogene (Klein 1983). These specific chromosomal translocations can occur 5′ or 3′ of the c-myc oncogene and are believed to cause deregulation of expression of c-myc. This is supported by the fact that in these tumors only the c-myc gene involved in the translocation is expressed (Taub 1984).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Denny CT, Hollis GF, Magrath IT, and Kirsch IR (1985) Burkitt lymphoma cell line carrying a variant translocation creates new DNA at the breakpoint and violates the hierarchy of immunoglobulin gene rearrangement. Molecular and Cellular Biology 5:3199′3207
Gazdar AF, Oie HK, Kirsch IR, and Hollis GF (1986) Establishment and characterization of a human plasma cell myeloma culture having rearranged cellular myc proto-oncogene. Blood (in press)
Hollis GF, Mitchell KF, Battey J, Potter H, Taub RA, Lenoir G, and Leder P (1984) A variant translocation places the lambda immunoglobulin genes 3′ to the c-myc oncogene in Burkitt lymphoma. Nature 307: 752–755
Klein G (1983) Specific chromosomal translocations and the genesis of B-cell derived tumors in mice and men. Cell 32: 311–315
Taub R, Moulding C, Battey J, Murphy W, Vasicek T, Lenoir G, and Leder P (1984) Activation and somatic mutation of the translocated c-myc gene in Burkitt lymphoma cells. Cell 36: 339–348
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Hollis, G.F., Gazdar, A.F., Kirsch, I.R. (1986). DNA Rearrangement and Expression of the c-myc Gene in a Human Myeloma. In: Melchers, F., Potter, M. (eds) Mechanisms in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71562-4_33
Download citation
DOI: https://doi.org/10.1007/978-3-642-71562-4_33
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71564-8
Online ISBN: 978-3-642-71562-4
eBook Packages: Springer Book Archive