DNA Rearrangement and Expression of the c-myc Gene in a Human Myeloma
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In both Burkitt’s lymphomas and murine plasmacytomas there are specific disease-associated chromosomal translocations that bring into contiguity one of the immunoglobulin gene loci with the c-myc proto-oncogene (Klein 1983). These specific chromosomal translocations can occur 5′ or 3′ of the c-myc oncogene and are believed to cause deregulation of expression of c-myc. This is supported by the fact that in these tumors only the c-myc gene involved in the translocation is expressed (Taub 1984).
KeywordsBurkitt Lymphoma Plasma Cell Myeloma Burkitt Lymphoma Cell Variant Translocation Immunoglobulin Gene Rearrangement
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