DNA Rearrangement and Expression of the c-myc Gene in a Human Myeloma

  • G. F. Hollis
  • A. F. Gazdar
  • I. R. Kirsch
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

In both Burkitt’s lymphomas and murine plasmacytomas there are specific disease-associated chromosomal translocations that bring into contiguity one of the immunoglobulin gene loci with the c-myc proto-oncogene (Klein 1983). These specific chromosomal translocations can occur 5′ or 3′ of the c-myc oncogene and are believed to cause deregulation of expression of c-myc. This is supported by the fact that in these tumors only the c-myc gene involved in the translocation is expressed (Taub 1984).

Keywords

Lymphoma Myeloma Plasmacytomas 

References

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • G. F. Hollis
    • 1
    • 2
  • A. F. Gazdar
    • 1
    • 2
  • I. R. Kirsch
    • 1
    • 2
  1. 1.NCI-Navy Medical Oncology BranchNational Institutes of HealthBethesdaUSA
  2. 2.National Cancer InstituteNational Institutes of HealthBethesdaUSA

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