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Benign Monoclonal Gammapathy (BMG)

Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

The term Idiopathic Paraproteinaemia or Benign Monoclonal Gammapathy (BMG) has been known to clinicians already for more than fourty years. It is used to denominate a condition characterized by the presence in serum of a homogeneous immunoglobulin (H-Ig) component persisting at a -more or less- constant concentration over many years, usually until the individual’s death (for a review see Radl, 1982). The concentration of such a H-lg component is usually less than 2 g/dl and the level of lg classes and subclasses other than those of the H-Ig may be normal or decreased but never to such an extent as seen in multiple myeloma (MM) or Waldenstrom’s macroglobulinaemia (WM). The class distribution of H-Ig is approximately 60%, 20% and 20% for IgG, IgA and IgM, respectively. Bence Jones proteinaemia and/or proteinuria, frequent in MM and WM, is very rare in BMG. When investigating the bone marrow cells, an increased monoclonal proliferation is found; however, these cells do not posses morphological abnormalities and they do not reach such a dominance as found in plasma cell malignancies. The benign character of this plasma cell proliferation is also reflected in the absence of bone destruction. The occurrence of BMG is clearly age-related: starting in the fourth decade, its frequency increases up to almost 20% in the tenth decade of life. The ratio of the incidence of malignant versus non-malignant monoclonal gammapathies (MG) can be estimated as about 1:200. Within the non-malignant MG, the BMG may represent about 50% of the cases.

Keywords

Multiple Myeloma Nude Athymic Mouse Proliferative Disorder BALB Mouse Monoclonal Proliferation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Kyle RA, Greipp PR (1980) Smoldering multiple myeloma. New Eng J Med 302: 1347–1349.PubMedCrossRefGoogle Scholar
  2. Radl J, Hollander CF, van den Berg P and de Glopper E (1978) Idiopathic paraproteinaemia I. Studies in an animal model - the ageing C57BL/Ka- LwRij mouse. Clin exp Immunol 33: 395–402.PubMedGoogle Scholar
  3. Radl J, (1979) Idiopathic paraproteinemia - a consequence of an age-related deficiency in the T immune system. Three-stage development - a hypothesis. Clin Immunol Immunopathol 14: 251–255.PubMedCrossRefGoogle Scholar
  4. Radl J, de Glopper E, Schuit HRE, Zurcher C (1979) Idiopathic paraproteinemia II. Transplantation of the paraprotein producing clone from old to young C57BL/KaLwRij mice. J Immunol 122: 609–613.Google Scholar
  5. Radl J, Mink, JG, van den Berg P, van Zwieten, MJ and Benner, R (1980a) Increased frequency of homogenous immunoglobulins in the sera of nude athymic mice with age. Clin Immunol Immunopathol 17: 469–476.PubMedCrossRefGoogle Scholar
  6. Radl J, de Glopper E, van den Berg P and van Zwieten M.J. (1980b) Idiopathic paraproteinemia. III. Increased frequency of paraproteinemia in thymectomized aging C57BL/KaLwRij and CBA/BrARij mice. J Immunol 125: 31–35.Google Scholar
  7. Radl J (1981) Benign monoclonal gammopathy (Idiopathic paraproteinemia). Amer J Pathol 105: 91–93.Google Scholar
  8. Radl J (1982) Effects of aging on immunoglobulins. In: Ritzman, SE, (ed) Pathology of immunoglobulins: Diagnostic and Clinical Aspects, Protein abnormalities, Vol. 2,, Alan R. Liss, Inc., New York, N.Y., p 55–69.Google Scholar
  9. Radl J, Heidt PJ, Knaan-Shanzer S and van Zwieten MJ (1984) Idiopathic paraproteinaemia. IV. The role of genetic factors in the development of monoclonal B cell proliferative disorders - a study in the ageing C57BL/KaLwRij and CBA/BrARij mouse radiation chimeras. Clin exp Immunol 57: 213–216.Google Scholar
  10. Radi J, van den Enden-Vieveen MHM, van de Akker TW, Benner R, Haaijman JJ and Zürcher C (1985) Idiopathic paraproteinaemia. V. Expression of lgh1 and Igh5 allotypes within the homogeneous immunoglobulins of ageing (C57BL/ LiARij x CBA/BrARij)F1 mouse. Clin. Exp. Immunol. 62: 405–411Google Scholar
  11. Radi, J (1985) Monoclonal Gammapathies - an attempt at a new classification. Neth J Med 28: 134–137.Google Scholar
  12. Radi J, Croese JW, Zürcher C, Brondijk RJ and van den Enden-Vieveen MHM (1985) Spontaneous multiple myeloma with bone lesions in the aging C57BL/KaLwRij mouse as a natural model of human disease. In: Radi, J, Hijmans, W. and van Camp, B (eds) Monoclonal gammapathies, Clinical significance and basic mechanisms, EURAGE, Rijswijk, p. 191–194.Google Scholar
  13. Van de Akker TW, Tio-Gillen AP, Benner R, Zürcher C, Radi J (1986) Idiopathic paraproteinaemia VI. The development of “Benign monoclonal gammapathy” in aging H2 congenic C57BL and BALB mice is independent on their H2 haptotype (in preparation).Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • J. Radl
    • 1
  1. 1.TNO Institute for Experimental GerontologyRijswijkThe Netherlands

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