Restrictions That Influence Avian Leukosis Virus-Induced Lymphoid Leukosis

  • Eric H. Humphries
  • Timothy W. Baba
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)


Infection of one day old White leghorn chicks with avian leukosis virus (ALV) usually results in the development of a bursal- dependent B-cell lymphoma (Purchase and Burmester, 1978). This tumor requires the bursal environment to develop and is characterized by the presence of cell surface immunoglobulin M (IgM) (Cooper et al., 1974). Integration of the ALV provirus within the normal c-myc locus of the target cell disrupts the expression of this locus and appears to be important in the development of the primary tumor (Hayward et al., 1981; Payne et al., 1982). However, alterations that influence the expression of the c-myc locus have been implicated in the development of a variety of lymphoid tumors in several species (Dalla-Favera et al., 1982; Shen-Ong et al., 1982; Corcoran et al., 1984; Levy et al., 1984). These lymphoid tumors exhibit considerable variation in their phenotype and include not only B-cell tumors that express IgM but also mature B-cell tumors that secrete IgG and T-cell tumors. It is not known why ALV infection produces such a restricted type of lymphoid tumor in the chicken. A variety of factors including (i) access of the virus to a particular type of target tissue, (ii) the abundance and proliferative capacity of different target cells at the time of virus replication and (iii) specific and non-specific host defense mechanisms could influence tumor development following ALV infection.


Infectious Virus Haploid Genome Lymphoid Tumor Preneoplastic Lesion Avian Leukosis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Baba TW, Humphries EH (1984) Avian leukosis virus infection: analysis of viremia and DNA integration in susceptible and resistant chicken lines. J Virol 51: 123–130PubMedGoogle Scholar
  2. Baba TW, Humphries EH (1985) Formation of a transformed follicle is necessary but not sufficient for development of an avian leukosis virus-induced lymphoma. Proc Natl Acad Sci USA 82: 213–216PubMedCrossRefGoogle Scholar
  3. Cooper MD, Purchase HG, Bochman DE, Gathings WE (1974) Studies on the nature of the abnormality of B cell differentiation in avian lymphoid leukosis: Production of heterogeneous IgM by tumor cells. J Immunol 133: 1210–1222Google Scholar
  4. Corcoran LM, Adams JM, Dunn AR, Cory S (1984) Murine lymphomas in which the cellular myc oncogene has been activated by retroviral insertion. Cell 37: 113–122PubMedCrossRefGoogle Scholar
  5. Dalla-Favera R, Bregni M, Erickson J, Patterson D, Gallo RC, Croce CM (1982) Human c-myc oncogene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci USA 79: 7824–7828PubMedCrossRefGoogle Scholar
  6. De Boer GF, Maas HJL, Van Vloten J, Groenendal JE (1981) Horizontal transmission of lymphoid leukosis virus; Influence of age, maternal antibodies and degree of contact exposure. Avian Path 10: 343–358Google Scholar
  7. Fung Y-K, Fadley AM, Crittenden LB, Kung H-J (1982) Avian lymphoid leukosis virus infection and DNA integration in the preleukotic bursal tissues: a comparative study of susceptible and resistant lines. Virology 119: 411–421PubMedCrossRefGoogle Scholar
  8. Hayward WS, Neel BG, Astrin SM (1981) Activation of a cellular one gene by promoter insertion in ALV-induced lymphoid leukosis. Nature (London) 290: 475–480CrossRefGoogle Scholar
  9. Levy LS, Gardner MB, Casey JW (1984) Isolation of a feline leukaemia provirus containing the oncogene myc from a feline lymphosarcoma. Nature (London) 308: 853–856CrossRefGoogle Scholar
  10. Payne GS, Bishop JM, Varmus HE (1982) Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas. Nature (London) 295: 209–214CrossRefGoogle Scholar
  11. Purchase HG, Burmester BR (1978) Diseases of Poultry. Iowa State University Press, Iowa, p 418Google Scholar
  12. Shen-Ong GCL, Keath EJ, Piccoli SP, Cole MD (1982) Novel myc oncogene RNA from abortive immunoglobulin-gene recombination xn mouse plasmacytomas. Cell 31: 443–452PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • Eric H. Humphries
    • 1
  • Timothy W. Baba
    • 1
  1. 1.Department of Microbiology, Southwestern Medical SchoolThe University of Texas Health Science CenterDallasUSA

Personalised recommendations