Chromosomal Radiosensitivity During G2 Phase and Susceptibility to Plasmacytoma Induction in Mice
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Genetic differences in susceptibility to plasmacytoma induction among inbred strains of mice are well documented. Whether induced by i. p. implantation of plastic discs or injection of pristane, the BALB/c mouse, in contrast to most other commonly used inbred strains, is significantly more susceptible (Merwin and Redmon, 1963; Morse et al., 1980; Potter et al., 1984). The F1 hybrid between BALB/c and a resistant strain such as DBA/2 is resistant. This and other findings on hybrid crosses suggest that specific genes for susceptibility and/or resistance determine tumor incidence (Potter et al., 1975; Potter and Wax, 1981). Studies are in progress to identify these genes through the development of congenic BALB/c sublines carrying genes from a resistant strain. Particularly useful in this endeavor is the BALB/cJ mouse, which was separated in 1937 from the BALB/cAn subline; although showing minimal genetic drift in most properties, the BALB/cJ mouse is resistant to plasmacytoma induction (Potter and Wax, 1981, 1985).
KeywordsMetaphase Cell Metacentric Chromosome Chromatid Break Normal Skin Fibroblast Nat1 Cancer Inst
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