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Chromosomal Radiosensitivity During G2 Phase and Susceptibility to Plasmacytoma Induction in Mice

  • K. K. Sanford
  • R. Parshad
  • M. Potter
  • G. M. Jones
  • R. P. Nordan
  • S. E. Brust
  • F. M. Price
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

Genetic differences in susceptibility to plasmacytoma induction among inbred strains of mice are well documented. Whether induced by i. p. implantation of plastic discs or injection of pristane, the BALB/c mouse, in contrast to most other commonly used inbred strains, is significantly more susceptible (Merwin and Redmon, 1963; Morse et al., 1980; Potter et al., 1984). The F1 hybrid between BALB/c and a resistant strain such as DBA/2 is resistant. This and other findings on hybrid crosses suggest that specific genes for susceptibility and/or resistance determine tumor incidence (Potter et al., 1975; Potter and Wax, 1981). Studies are in progress to identify these genes through the development of congenic BALB/c sublines carrying genes from a resistant strain. Particularly useful in this endeavor is the BALB/cJ mouse, which was separated in 1937 from the BALB/cAn subline; although showing minimal genetic drift in most properties, the BALB/cJ mouse is resistant to plasmacytoma induction (Potter and Wax, 1981, 1985).

Keywords

Metaphase Cell Metacentric Chromosome Chromatid Break Normal Skin Fibroblast Nat1 Cancer Inst 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • K. K. Sanford
    • 1
  • R. Parshad
    • 1
    • 2
  • M. Potter
    • 1
    • 3
  • G. M. Jones
    • 1
  • R. P. Nordan
    • 1
    • 3
  • S. E. Brust
    • 1
    • 3
  • F. M. Price
    • 1
  1. 1.Laboratory of Cellular and Molecular BiologyNational Cancer InstituteBethesdaUSA
  2. 2.Department of PathologyHoward University College of MedicineWashington, DCUSA
  3. 3.Laboratory of GeneticsNational Cancer InstituteBethesdaUSA

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