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Mechanisms in B-Cell Neoplasia pp 183–192Cite as

Molecular Genetics of Human B-cell Neoplasia

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 132))

Abstract

Specific chromosome rearrangements, predominantly translocations and inversions, are observed in the great majority of human hematopoietic malignancies (Van Den Berghe, et. al. 1978, Yunis et. al. 1982, 1984). In Burkitt lymphoma the specific chromosomal translocations involve directly one of the human immunoglobulin loci and the c-myc oncogene (Dalla Favera, et. al. 1982, Croce, et. al. 1983, Erikson et. al. 1983). The consequence of the juxtaposition of the immunoglobulin loci and of the c-myc oncogene is a deregulation of the transcription of the involved c-myc oncogene that is transcribed constitutively at elevated levels (Croce, et. al. 1983, Erikson, et. al. 1983, Nishikura, et. al. 1983). Other specific chromosomal translocations involving band 14q32, where the immunoglobulin heavy chain locus resides (Croce et. al. 1979, Erikson et. al. 1982), are observed in B cell neoplasms. A t(11;14) (q13;q32) chromosome translocation has been observed in chronic lymphocytic leukemia of the B cell type (Nowell et. al. 1981), in diffuse B cell lymphoma (Yunis et. al. 1982, 1984) and in multiple myeloma (Van Den Berghe et. al. 1984). This translocation juxtaposes the bcl-1 locus to the heavy chain locus (Tsujimoto et. al. 1984, 1985a, b). In most cases of follicular lymphoma, one of the most common human hematopoietic maligancies, a t(14;18) (q32;q21) chromosome translocation has been observed (Yunis et. al. 1982, 1984).

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Authors and Affiliations

  1. The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA

    Y. Tsujimoto & C. M. Croce

Authors
  1. Y. Tsujimoto
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  2. C. M. Croce
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Editor information

Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstr. 487, CH-4005, Basel, Germany

    Fritz Melchers

  2. Laboratory of Genetics, National Institutes of Health, 20892, Bethesda, MD, USA

    Michael Potter M.D. (Chief) (Chief)

  3. National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA

    Michael Potter M.D. (Chief) (Chief)

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© 1986 Springer-Verlag Berlin · Heidelberg

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Tsujimoto, Y., Croce, C.M. (1986). Molecular Genetics of Human B-cell Neoplasia. In: Melchers, F., Potter, M. (eds) Mechanisms in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71562-4_27

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  • DOI: https://doi.org/10.1007/978-3-642-71562-4_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71564-8

  • Online ISBN: 978-3-642-71562-4

  • eBook Packages: Springer Book Archive

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