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Molecular Genetics of Human B-cell Neoplasia

  • Y. Tsujimoto
  • C. M. Croce
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

Specific chromosome rearrangements, predominantly translocations and inversions, are observed in the great majority of human hematopoietic malignancies (Van Den Berghe, et. al. 1978, Yunis et. al. 1982, 1984). In Burkitt lymphoma the specific chromosomal translocations involve directly one of the human immunoglobulin loci and the c-myc oncogene (Dalla Favera, et. al. 1982, Croce, et. al. 1983, Erikson et. al. 1983). The consequence of the juxtaposition of the immunoglobulin loci and of the c-myc oncogene is a deregulation of the transcription of the involved c-myc oncogene that is transcribed constitutively at elevated levels (Croce, et. al. 1983, Erikson, et. al. 1983, Nishikura, et. al. 1983). Other specific chromosomal translocations involving band 14q32, where the immunoglobulin heavy chain locus resides (Croce et. al. 1979, Erikson et. al. 1982), are observed in B cell neoplasms. A t(11;14) (q13;q32) chromosome translocation has been observed in chronic lymphocytic leukemia of the B cell type (Nowell et. al. 1981), in diffuse B cell lymphoma (Yunis et. al. 1982, 1984) and in multiple myeloma (Van Den Berghe et. al. 1984). This translocation juxtaposes the bcl-1 locus to the heavy chain locus (Tsujimoto et. al. 1984, 1985a, b). In most cases of follicular lymphoma, one of the most common human hematopoietic maligancies, a t(14;18) (q32;q21) chromosome translocation has been observed (Yunis et. al. 1982, 1984).

Keywords

Follicular Lymphoma Chromosome Translocation Involve Band 14q32 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • Y. Tsujimoto
    • 1
  • C. M. Croce
    • 1
  1. 1.The Wistar InstitutePhiladelphiaUSA

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