Advertisement

C-Myc Activation in Spontaneous Rat Immunocytomas Containing a 6;7 Chromosomal Translocation

  • Warren S. Pear
  • Gunilla Wahlström
  • Stanley F. Nelson
  • Sigurdur Ingvarsson
  • Hervé Bazin
  • George Klein
  • Janos Sumegi
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

The Lou/Wsl rat immunocytoma (RIC) is a plasma cell tumor (Bazin et al, 1972; for review, see Bazin, 1986), and histologically resembles the mouse plasmacytoma. Tumors arise spontaneously in the ileocecal lymph nodes in approximately 28% of rats of the Lou/Wsl strain, and are detectable at about one year of age. The tumors kill the animals approximately one month after becoming palpable. Although the most frequently secreted myeloma protein is IgE, all isotypes and Bence-Jones proteins are secreted. In addition to the genetic predisposition of the Lou/Wsl strain, both parasites and sex have been postulated as factors in immunocytoma development (Bazin, 1985).

Keywords

Chromosomal Translocation Immunoglobulin Heavy Chain Plasma Cell Tumor Light Chain Locus Opposite Transcriptional Orientation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bazin, H, Deckers, C, Beckers, A, and Heremans, JF (1972) Transplantable Ig-secreting tumors in rats. Int. J. Cancer 10: 568–580.PubMedCrossRefGoogle Scholar
  2. Bazin, H (1985). In: Mechanisms of B Cell Neoplasia. Editiones Roche, Basil, p. 208.Google Scholar
  3. Bazin, H (1986) Louvain rat immunocytomas. Adv. Cancer Res.: in press.Google Scholar
  4. Corcoran, LM, Adams, JM, Dunn, AR, and Cory, S (1984) Transposition of the immunoglobulin heavy chain enhancer to the myc oncogene in a murine plasmacytoma. Cell 40: 71–79.CrossRefGoogle Scholar
  5. Cory, S (1986) Activation of cellular oncogenes in hemopoietic cells by chromosomal translocation. Adv Cancer Res: in press.Google Scholar
  6. Dalla-Favera, R, Gelmann, EP, Martinotti, S, Franchini, G, Papas, T, Gallo, R, and Wong-Staal, F (1 9 8 2) Cloning and characterization of different human sequences related to the one gene (v-myc) of avian myelocytomatosis virus (MC29). Proc. Natl. Acad. Sci. USA 79: 6497–6501.Google Scholar
  7. Klein, G and Klein, E (1985) Myc/Ig juxtaposition by chromosomal translocation: some new insights, puzzles, and paradoxes. Immunology Today 6: 208–215.CrossRefGoogle Scholar
  8. Li, Y, Holland, CA, Hartley, JW, and Hopkins, N (1984) Viral integration near c-myc in 10–20% of MCF 247-induced AKR lymphomas. Proc. Natl. Acad. Sci. USA 81: 6808–6811.Google Scholar
  9. Pear, WS, Wahlstrom, G, Szpirer, J, Levan, G, Klein,G, and Sumegi, J (1986) Localization of the rat immunoglobulin heavy chain locus to chromosome 6. Immunogenetics: in press.Google Scholar
  10. Perlmann, C, Sumegi, J, Szpirer, C, Levan, G, and Klein, G (1985) The rat immunoglobuliln kappa light chain locus is on chromosome 4. Immunogenetics 22: 97–100.PubMedCrossRefGoogle Scholar
  11. Selton, G, Cuypers, HT, Zijlstra, M, Melief, C, and Berns, A (1984) Involvement of c-myc in MULV-induced T cell lymphomas in mice: frequency and mechanisms of activation. EMBO J. 3: 3215–3222.Google Scholar
  12. Steffen, D (1984) Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas. Proc. Natl. Acad. Sci. USA 81: 2097–2101.PubMedCrossRefGoogle Scholar
  13. Szpirer, J, Levan G, Thorn, M, and Szpirer, C (1984) Gene mapping in the rat by mouse-rat somatic cell hybridization: synteny of the albumin and alpha-fetoprotein genes and assignment to chromosome 14. Cytogenet. Cell Genet. 38: 142–149.Google Scholar
  14. Sumegi, J, Spira, J, Bazin, H, Szpirer, J, Levan, G, and Klein, G (1983) Rat c-myc is located on chromosome 7 and rearranges in immunocytomas with t(6;7) chromosomal translocation. Nature 306: 497–498.PubMedCrossRefGoogle Scholar
  15. Wiener, F, Babonits, M, Spira, J, Klein, G, and H Bazin (1982) Non-random chromosomal changes involving chromosomes 6 and 7 in spontaneous rat immunocytomas. Int. J. Cancer 29: 431–437.Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • Warren S. Pear
    • 1
  • Gunilla Wahlström
    • 1
  • Stanley F. Nelson
    • 1
  • Sigurdur Ingvarsson
    • 1
  • Hervé Bazin
    • 1
    • 2
  • George Klein
    • 1
  • Janos Sumegi
    • 1
  1. 1.Dep’t of Tumor BiologyKarolinska InstituteStockholmSweden
  2. 2.Experimental Immunology Unit, Faculty of MedicineUniversity of LouvainBrusselsBelgium

Personalised recommendations