Possible Role of Immunoglobulin Recombination Sequences in the Genesis of Variant t(2;8) Translocations of Burkitt Lymphoma
Various chromosomal abberations have been regularly found in cytogenetic investigations and can be associated with specific human neoplasia (Rowley 1980; Yunis 1983). However, few of them are accessible to molecular analysis providing the necessary information for understanding the mechanisms and functional consequences of such drastic changes in the otherwise higly conserved structural order of genetic material. Some of the best analyzed examples are human Burkitt lymphomas and murine plasmacytomas carrying consistently a reciprocal translocation (t(8,14), t(2;8), and t(8;22) in man, and t(12;15) and t(6;15) in mice) which always involves one of the immunoglobulin heavy or light chain genes and the locus of the c-myc oncogene on human chromosome 8 and on mouse chromosome 15 (for review see Klein 1983, 1985)). Although a lot of new information has accumulated recently, the available data do not allow one to propose an unifying hypothesis explaining the mechanisms responsible for the genesis of translocations and for the activation of the c-myc gene.
KeywordsLymphoma Recombination Kelly Dinucleotide Phoma
Unable to display preview. Download preview PDF.
- Emanuel BS, Selden JR, Chaganti RSK, Jhanwar S, Nowell PC, Croce CM (1 984) The 2p breakpoint of a 2;8 translocation in Burkitt lymphoma interrupts the VV. locus. Proc Natl Acad Sci USA 81: 2444–2446Google Scholar
- Hieter PA, Maizel JV, Leder P (1982) Evolution of human immuno-globulin kappa J region genes. J Biol Chem 257: 1516–1522Google Scholar
- Kelley DE, Wiedemann LM, Pittet A-C, Strauss S, Nelson KJ, Davis J, Van Ness B, Perry RP (1985) Nonproductive kappa immunoglobulin genes: Recombinational abnormalities and other lesions affecting transcription, RNA processing, turnover, and translation. Mol Cell Biol 5: 1660–1675Google Scholar
- Mark-Vendel E, Philip T, Ladjaj Y, Aboulola M, Lenoir GM (1983) Chromosomal translocation in algerian Burkitt’s lymphoma. The Lancet ii: 788Google Scholar
- Rappold GA, Hameister H, Cremer T, Adolph S, Henglein B, Freese U-K, Lenoir GM, Bornkamm GW (1984) c-myc and immunoglobulin kappa light chain constant genes are on the 8q+ chromosome of three Burkitt lymphoma lines with t(2;8) translocation. EMBO J 3: 2951–2955Google Scholar