Possible Role of Immunoglobulin Recombination Sequences in the Genesis of Variant t(2;8) Translocations of Burkitt Lymphoma
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Various chromosomal abberations have been regularly found in cytogenetic investigations and can be associated with specific human neoplasia (Rowley 1980; Yunis 1983). However, few of them are accessible to molecular analysis providing the necessary information for understanding the mechanisms and functional consequences of such drastic changes in the otherwise higly conserved structural order of genetic material. Some of the best analyzed examples are human Burkitt lymphomas and murine plasmacytomas carrying consistently a reciprocal translocation (t(8,14), t(2;8), and t(8;22) in man, and t(12;15) and t(6;15) in mice) which always involves one of the immunoglobulin heavy or light chain genes and the locus of the c-myc oncogene on human chromosome 8 and on mouse chromosome 15 (for review see Klein 1983, 1985)). Although a lot of new information has accumulated recently, the available data do not allow one to propose an unifying hypothesis explaining the mechanisms responsible for the genesis of translocations and for the activation of the c-myc gene.
KeywordsBurkitt Lymphoma Kappa Light Chain BamHI Fragment Recombination Signal Sequence Chromosomal Breakpoint
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