Abstract
Analyses of chromosomal aberrations associated with specific cancers are providing insight into fundamental issues of cellular development and differentiation as well as oncogenesis. We have previously reported our findings in support of the concept that chromosomal aberrations often reflect the particular differentiated state of the cells and cell types in which they occur (Kirsch 1985). This concept developed not just from data dealing with the involvement of immunoglobulin genes in the chromosomal aberrations seen in Burkitt’s and other B cell tumors, but also from observations we reported on the involvement of the globin encoding regions in translocations seen in erythroleukemias. It was with this as a foundation that we speculated that chromosomal aberrations associated with T cell disorders might involve chromosomal regions to which T cell specific functions would be localized. This prediction has now been fulfilled as we (Caccia 1985) and others (Croce 1985, Isobe 1985, LeBeau 1985, Morton 1985, Murre 1985) have localized the alpha, beta, and gamma chains of the T cell antigen receptor to three of the four most common and consistent hotspots of chromosomal breakage in malignant and non-malignant (or pre-mal ignant) T cells (Kaiser-McCaw 1975, Aurias 1980, Scheres 1980, Wake 1982, Taylor 1982, Williams 1984, Zech 1984, Smith 1986)
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Aurias A, Dutrillaux B, Buriot D, Lejeune J (1980) High frequencies of Inversions and transiocatlons of chromosomes 7 and 14 In ataxia telangiectasia. Mutation Research 69: 369–374
Caccia N, Bruns GAP, Kirsch IR, Hollis GF, Bertness V, Mak TW (1985) T cell receptor alpha chain genes are located on chromosome 14 at 14ql1-14ql2 in humans. J Exp Med 161: 1255–1260
Croce CM, Isobe M, Palumbo A, Puck J, Ming J, Tweardy D, Erikson J, Davis M, Rovera G (1985) Gene for alpha-chain of human T-cel1 receptor: Location on chromosome 14 region involved in T-cell neoplasms. Science 277: 1044–1047.
Denny CT, Yoshikai Y, Mak TW, Smith SD, Hollis GF, Kirsch IR (1986) A chromosome 14 inversion in a T cell lymphoma is caused by site- specific recombination between immunoglobulin and T cell receptor loci. Nature 320: 549–551
Isobe M, Erikson J, Emanuel BS, Nowell PC, Croce CM (1985) Location of gene for beta subunit of human T-cell receptor at band 7q35 a region prone to rearrangement in T cells. Science 228: 580–582
Kaiser-McCaw B, Hecht F, Harnden DG, Teplitz RL (1975) Somatic rearrangement of chromosome 14 in human lymphocytes. Proc Natl Acad Sci USA 72: 2071–1075.
Kirsch IR, Brown JA, Lawrence J, Korsmeyer S, Morton CC (1985) Translocations that highlight chromosomal regions of differentiated activity. Cancer Genet Cytogenet 18: 159–171.
Kirsch IR, Denny CT, Bertness V, Smith SD, Hollis GF (submitted) Disruption of the c-myc protooncogene in a human T cell lymphoma cell line
LeBeau MM, Diaz MO, Rowley JD, Mak TW (1985) Chromosomal localization of the human T cell receptor beta-chain genes. Cell 41: 335
Morton CC, Duby AD, Eddy RL, Shows TB, Seidman JG (1985) Genes for beta chain of human T cell antigen receptor map to regions of chromosomal rearrangements in T cells. Science 228: 582–585
Murre C, Waldmann RA, Morton CC, Bongiovanni KF, Waldman TA, Shaws TB, Seidman JG (1985) Human gamma-chain genes are rearranged in leukemic T cells and map to the short arm of chromosome 7. Nature 316: 549–552
Scheres JMJC, Hustinx TWJ, Weemaes CMR (1980) Chromosome 7 in ataxia-telangictaxia. J Pediatr 97: 440–441
Smith SD, Morgan R, Link MP, McFall P, Hecht F (1986) Cytogenetic and immunophenotypic analysis of cell lines established from patients with T cell 1eukemia/lymphoma. Blood 67: 650–656
Taylor AMR (1982) Cytogenetics of ataxia-telangictasia. In: Bridges BA and Harndern DG (eds) Ataxia-telangiectasia: A cellular link between cancer, neuropathology, and immunodeficiency. John Wiley and Sons, New York, pp 53–81
Wake N, Minowada J, Park B, Sandberg AA (1982) Chromosomes and causation of human cancer and leukemia. XLVII. T-cell acute leukemia in ataxia-telangiectasia. Cancer Genet Cytogenet 6: 345–357.
Williams DL, Look AT, Melvin SL, Roberson PK, Dahl G, Flake T, Stass S (1984) New chromosomal translocations correlate with specific immunophenotypes of childhood acute lymphoblastic leukemia. Cell 36: 101–109
Yancopoulos GD, Blackwell TK, Suh H, Hood L, Alt FW (1986) Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase. Cell 44: 251–259
Zech L, Gahrton G, Hammarstrom L, Juliusson G, Mellstedt H, Robert KH, Smith CIE (1984) Inversion of chromosome 14 marks human T-cell chronic lymphocytic leukemia. Nature 308: 858–860
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© 1986 Springer-Verlag Berlin · Heidelberg
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Kirsch, I.R., Denny, C.T., Hollis, G.F. (1986). Genomic Activity and Translocation in Lymphocytes. In: Melchers, F., Potter, M. (eds) Mechanisms in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71562-4_23
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DOI: https://doi.org/10.1007/978-3-642-71562-4_23
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