Genomic Activity and Translocation in Lymphocytes

  • I. R. Kirsch
  • C. T. Denny
  • G. F. Hollis
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)


Analyses of chromosomal aberrations associated with specific cancers are providing insight into fundamental issues of cellular development and differentiation as well as oncogenesis. We have previously reported our findings in support of the concept that chromosomal aberrations often reflect the particular differentiated state of the cells and cell types in which they occur (Kirsch 1985). This concept developed not just from data dealing with the involvement of immunoglobulin genes in the chromosomal aberrations seen in Burkitt’s and other B cell tumors, but also from observations we reported on the involvement of the globin encoding regions in translocations seen in erythroleukemias. It was with this as a foundation that we speculated that chromosomal aberrations associated with T cell disorders might involve chromosomal regions to which T cell specific functions would be localized. This prediction has now been fulfilled as we (Caccia 1985) and others (Croce 1985, Isobe 1985, LeBeau 1985, Morton 1985, Murre 1985) have localized the alpha, beta, and gamma chains of the T cell antigen receptor to three of the four most common and consistent hotspots of chromosomal breakage in malignant and non-malignant (or pre-mal ignant) T cells (Kaiser-McCaw 1975, Aurias 1980, Scheres 1980, Wake 1982, Taylor 1982, Williams 1984, Zech 1984, Smith 1986)


Chronic Lymphocytic Leukemia Chromosomal Aberration Cell Specific Function Cell Lymphoma Cell Line Immunoglobulin Heavy Chain Variable 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • I. R. Kirsch
    • 1
    • 2
  • C. T. Denny
    • 1
    • 2
  • G. F. Hollis
    • 1
    • 2
  1. 1.NCI-Navy Medical Oncology BranchNational Institutes of HealthBethesdaUSA
  2. 2.National Cancer InstituteNational Institutes of HealthBethesdaUSA

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