Structure and Expression of c-myb Protooncogene mRNA in Murine B-Cells

  • T. P. Bender
  • W. M. Kuehl
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)


The c-myb proto-oncogene, which encodes a nuclear DNA binding protein (Boyle 1984, Kempnauer 1984) has been reported to be expressed predominantly in normal tissue and tumor cells of hematopoietic origin (Westin 1982; Gonda 1982). Moreover, for each hematopoietic lineage examined, the steady state levels of c-myb mRNA expression are highest in immature cells. These properties of the c-myb gene and its products are consistent with the idea that c-myb regulates hematopoietic maturation by controlling the expression of other genes. We have begun to examine this hypothesis using B-cell tumor lines.


Hybrid Cell Line Primary Translation Product Uninduced Culture Virus Transformed Cell Line Abelson Virus 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • T. P. Bender
    • 1
    • 2
    • 3
  • W. M. Kuehl
    • 1
    • 2
    • 3
  1. 1.NCI-Navy Medical Oncology BranchNational Institutes of HealthBethesdaUSA
  2. 2.National Cancer InstituteNational Institutes of HealthBethesdaUSA
  3. 3.Naval HospitalBethesdaUSA

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