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Structure and Expression of c-myb Protooncogene mRNA in Murine B-Cells

  • T. P. Bender
  • W. M. Kuehl
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

The c-myb proto-oncogene, which encodes a nuclear DNA binding protein (Boyle 1984, Kempnauer 1984) has been reported to be expressed predominantly in normal tissue and tumor cells of hematopoietic origin (Westin 1982; Gonda 1982). Moreover, for each hematopoietic lineage examined, the steady state levels of c-myb mRNA expression are highest in immature cells. These properties of the c-myb gene and its products are consistent with the idea that c-myb regulates hematopoietic maturation by controlling the expression of other genes. We have begun to examine this hypothesis using B-cell tumor lines.

Keywords

Hybrid Cell Line Primary Translation Product Uninduced Culture Virus Transformed Cell Line Abelson Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • T. P. Bender
    • 1
    • 2
    • 3
  • W. M. Kuehl
    • 1
    • 2
    • 3
  1. 1.NCI-Navy Medical Oncology BranchNational Institutes of HealthBethesdaUSA
  2. 2.National Cancer InstituteNational Institutes of HealthBethesdaUSA
  3. 3.Naval HospitalBethesdaUSA

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