Structure and Expression of c-myb Protooncogene mRNA in Murine B-Cells
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The c-myb proto-oncogene, which encodes a nuclear DNA binding protein (Boyle 1984, Kempnauer 1984) has been reported to be expressed predominantly in normal tissue and tumor cells of hematopoietic origin (Westin 1982; Gonda 1982). Moreover, for each hematopoietic lineage examined, the steady state levels of c-myb mRNA expression are highest in immature cells. These properties of the c-myb gene and its products are consistent with the idea that c-myb regulates hematopoietic maturation by controlling the expression of other genes. We have begun to examine this hypothesis using B-cell tumor lines.
KeywordsHybrid Cell Line Primary Translation Product Uninduced Culture Virus Transformed Cell Line Abelson Virus
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