Studies on Transferrin Receptor Expression in Mouse Plasmacytoma Cells
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Transferrin receptor (TfR) expression in lymphoid cells is normally regulated by interaction of tissue-specific growth factors with their receptors (Neckers and Cossman 1983, Neckers et al. 1984). Malignant transformation of T and B lymphocytes generally leads to constitutive expression of TfR (Neckers 1985). Mouse plasmacytomas are an example of terminally differentiated B cells which continue to proliferate in an uncontrolled manner and constitutively express TfR in vivo. However, in vitro growth of most plasmacytomas requires the presence of a macrophage-derived growth factor (plasmacytoma growth factor, PCT-GF) described elsewhere in this volume (Nordan et al.; see also Nordan and Potter 1986). In this report we characterize the relationship between PCT-GF and TfR in plasmacytoma cell lines and describe a TfR mRNA species uniquely found in mouse plasmacytomas.
KeywordsTransferrin Receptor Mouse cDNA Plasma Cell Neoplasm Independent Cell Line Plasmacytoma Cell
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