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Studies on Transferrin Receptor Expression in Mouse Plasmacytoma Cells

  • L. M. Neckers
  • R. Nordan
  • S. Bauer
  • M. Potter
Conference paper
  • 49 Downloads
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

Transferrin receptor (TfR) expression in lymphoid cells is normally regulated by interaction of tissue-specific growth factors with their receptors (Neekers and Cossman 1983, Neekers et al. 1984). Malignant transformation of T and B lymphocytes generally leads to constitutive expression of TfR (Neekers 1985). Mouse plasmacytomas are an example of terminally differentiated B cells which continue to proliferate in an uncontrolled manner and constitutively express TfR in vivo. However, in vitro growth of most plasmacytomas requires the presence of a macrophage-derived growth factor (plasmacytoma growth factor, PCT-GF) described elsewhere in this volume (Nordan et al.; see also Nordan and Potter 1986). In this report we characterize the relationship between PCT-GF and TfR in plasmacytoma cell lines and describe a TfR mRNA species uniquely found in mouse plasmacytomas.

Keywords

Plasmacytoma Cell Human Mononuclear Leukocyte Plasmacytoma Cell Line Mouse Plasmacytomas Target Cell Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • L. M. Neckers
    • 1
    • 2
  • R. Nordan
    • 1
    • 2
  • S. Bauer
    • 1
    • 2
  • M. Potter
    • 1
    • 2
  1. 1.Laboratory of PathologyNCI, NIHBethesdaUSA
  2. 2.Laboratory of GeneticsNCI, NIHBethesdaUSA

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