Role of the LFA-1 Molecule in B Cell Differentiation
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The lymphocyte function-associated antigen-1 (LFA-1) was first identified as a T cell surface antigen, and antibodies to LFA-1 have been shown to inhibit responses of T cells to antigen and/or major histocompatibility complex (MHC) molecules (Springer 1982, Krensky 1983, Ware 1983, Collins 1984, Krensky 1984, Golde 1985, Naquet 1985). However, LFA-1 molecules are also present on the surface of B cells (Davignon 1981), and the possible functional role played by B cell LFA-1 has received little attention.
KeywordsMajor Histocompatibility Complex Phorbol Myristate Acetate Tissue Culture Supernatant Differentiative Signal 30C7 Dilution
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