Lymphokine Regulation of Murine IgE Production

  • Robert L. Coffman
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)


Many studies during the last 15 years have clearly established that IgE responses are regulated by T lymphocytes and that IgE production can be regulated independent of the production of other immunoglobulin isotypes (Ishizaka 1976; Itaya and Ovary 1979; Katz 1980). The mechanisms by which T cells effect this isotype-specific regulation of IgE, however, has not as yet been clearly defined. Much recent work has centered on the role of IgE-binding potentiator and suppressor factors in this regulation (Ishizaka 1984; Suemura et al. 1981; Young et al. 1984). In this report, we summarize evidence that B cell stimulatory factor-1 (BSF-1) and interferon-γ (IFN- γ) can also regulate IgE production in a relatively isotype-specific manner.


Immunoglobulin Isotype Cell Differentiation Factor Mast Cell Growth Factor Isotype Expression Cell Growth Factor Activity 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • Robert L. Coffman
    • 1
  1. 1.DNAX Research Institute of Molecular and Cellular BiologyPalo AltoUSA

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