Genes Affecting the Production or Action of B Cell-Active Lymphokines

  • C. L. Sidman
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)


Lymphokines are soluble polypeptides that appear to play important roles in controlling the immune system. The activation, proliferation, and differentiation of many cell types, including B lymphocytes (for reviews, see Holler 1984), are affected by these molecules in vitro. Tumor B cells differ from their nontransformed counterparts by virtue of their heightened proliferation and transplantability. Nevertheless, different activities of specific tumor B cell lines can still be regulated by lymphokines or other signals. A discussion of lymphokines is thus pertinent to the topic of B cell neoplasia in three ways. First, understanding the operation of lymphokines that regulate B cell development and function may yield insights into the cell populations giving rise to B cell neoplasia or the circumstances under which this occurs. Second, lymphokines may be important in controlling the fate and activity of transformed B cells in a tumor-bearing animal. Third, deliberate manipulation of the lymphokine system may eventually offer one or more modes of treatment for patients with B cell neoplasia.


Lambda Light Chain Cell Neoplasia Classical Genetic Analysis Deliberate Manipulation Immunological Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • C. L. Sidman
    • 1
  1. 1.The Jackson LaboratoryBar HarborUSA

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