Structural Modification of c-abl in Lymphoma and Leukemia
Vertebrate DNA contains a gene, named c-abl, that was disclosed by a rapidly oncogenic retrovirus, Abelson murine leukemia virus (A-MuLV)- A-MuLV carries a portion of c-abl (Goff et al., 1980) including a region encoding a protein-tyrosine kinase which is essential to the oncogenic activity of A-MuLV (Prywes et al., 1983). The cellular protein product of c-abl, like that of v-abl, is an active protein kinase (Konopka et al., 1985; Ben-Neriah et al., 1986a).
KeywordsLymphoma Tyrosine Leukemia Recombination Bromide
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