Structural Modification of c-abl in Lymphoma and Leukemia

  • Yinon Ben-Neriah
  • David Baltimore
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

Vertebrate DNA contains a gene, named c-abl, that was disclosed by a rapidly oncogenic retrovirus, Abelson murine leukemia virus (A-MuLV)- A-MuLV carries a portion of c-abl (Goff et al., 1980) including a region encoding a protein-tyrosine kinase which is essential to the oncogenic activity of A-MuLV (Prywes et al., 1983). The cellular protein product of c-abl, like that of v-abl, is an active protein kinase (Konopka et al., 1985; Ben-Neriah et al., 1986a).

Keywords

Lymphoma Tyrosine Leukemia Recombination Bromide 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • Yinon Ben-Neriah
    • 1
    • 2
  • David Baltimore
    • 1
    • 2
  1. 1.Whitehead Institute for Biomedical ResearchNine Cambridge CenterCambridgeUSA
  2. 2.Department of BiologyMassachusetts Institute of TechnologyCambridgeUSA

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