c-Myc-Induced Lymphomagenesis in Transgenic Mice and the Role of the Pvt-1 Locus in Lymphoid Neoplasia

  • Jerry M. Adams
  • Alan W. Harris
  • Wallace Y. Langdon
  • Carl A. Pinkert
  • Ralph L. Brinster
  • Richard D. Palmiter
  • Lynn Corcoran
  • Warren S. Alexander
  • Michael W. Graham
  • Suzanne Cory
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

Dysregulated expression of the c-myc proto-oncogene has been strongly implicated in lymphoid neoplasia, as reviewed by Leder et al (1984), Klein and Klein (1985), Adams and Cory (1985) and Cory (1986). In plasmacytomas of the mouse and Burkitt lymphomas of man, a predominant form of chromosomal translocation couples the c-myc gene to the IgH constant region locus, presumably bringing c-myc under the control of factors that regulate immunoglobulin expression. In someT lymphomas induced by retroviruses, a provirus has inserted near c-myc (e. g. Corcoran et al 1984). Thus strong circumstantial evidence links altired regulation of myc with lymphomagenesis. Typically, the alterations occur in the immediate vicinity of c-myc, but another class may involve long-range effects within the myc-bearing chromosome, as exemplified by the changes within the pvt-1 locus discussed later.

Keywords

Lymphoma Leukemia Adenocarcinoma Expense Kelly 

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References

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • Jerry M. Adams
    • 1
  • Alan W. Harris
    • 1
  • Wallace Y. Langdon
    • 1
  • Carl A. Pinkert
    • 2
  • Ralph L. Brinster
    • 2
  • Richard D. Palmiter
    • 3
    • 4
  • Lynn Corcoran
    • 1
  • Warren S. Alexander
    • 1
  • Michael W. Graham
    • 1
  • Suzanne Cory
    • 1
  1. 1.The Walter and Eliza Hall Institute of Medical ResearchP.O. Royal Melbourne HospitalMelbourneAustralia
  2. 2.Laboratory of Reproductive PhysiologySchool of Veterinary Medicine, University of PennsylvaniaPhiladelphiaUSA
  3. 3.Department of BiochemistryHoward Hughes Medical InstituteSeattleUSA
  4. 4.University of WashingtonSeattleUSA

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