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Effects of Dopamine-Rich Grafts on Sensorimotor Impairments in Dopamine-Depleted Rats

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Clinical Aspects of Sensory Motor Integration

Part of the book series: Advances in Applied Neurological Sciences ((NEUROLOGICAL,volume 4))

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Abstract

Following the description, in the early 1970s, of reliable techniques for the transplantation of neural tissues to the brains of experimental mammals [10, 34, 41], research effort focused on the use of grafts, primarily at the anatomical level, to study developmental processes and regenerative potential in the CNS [2, 27, 28]. However, once it became apparent that neural grafts can survive and grow in the brain, the question of the functional contribution of such grafts was raised. In particular, could it be possible to reconstruct or replace damaged neurones by transplantation in a manner sufficient to ameliorate impairments or restore lost functions disrupted by neurological lesions? In 1979, two reports appeared [3, 35] which demonstrated that grafts of embryonic dopamine (DA)-rich tissue to the forebrains of rats could reverse motor impairments associated with DA-depleting lesions.

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Author information

Authors and Affiliations

  1. Department of Experimental Psychology, Cambridge, CB2 3EB, UK

    S. B. Dunnett

  2. Department of Histology, S-223 62, Lund, Sweden

    A. Björklund

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  1. S. B. Dunnett
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  2. A. Björklund
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Editors and Affiliations

  1. Neurologische Klinik und Poliklinik, Technischen Universität München, Möhlstr. 28, D-8000, München 80, Germany

    Albrecht Struppler  & Adolf Weindl  & 

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© 1987 Springer-Verlag Berlin Heidelberg

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Dunnett, S.B., Björklund, A. (1987). Effects of Dopamine-Rich Grafts on Sensorimotor Impairments in Dopamine-Depleted Rats. In: Struppler, A., Weindl, A. (eds) Clinical Aspects of Sensory Motor Integration. Advances in Applied Neurological Sciences, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71540-2_38

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  • DOI: https://doi.org/10.1007/978-3-642-71540-2_38

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71542-6

  • Online ISBN: 978-3-642-71540-2

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