Neurologically Effective Nerve Growths in the Mammalian Brain: Recent Work of Tsukahara and Kawaguchi

  • J. C. Eccles
Conference paper
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 4)

Abstract

Until recently it was generally believed that all the embryonic know-how had been lost in the mammalian post-natal period so that there was no regeneration of the mammalian brain and spinal cord after injury. But now we have the encouraging prospect arising from well-designed experiments that there is a considerable regenerative capacity in several regions of the mammalian brain, even in adults. Optimistically, one can predict that we are only at the beginning of an enterprise in which various surgical procedures plus rehabilitation therapy, with, for example, local administration of nerve growth factors, will be able to reduce some of the disabilities suffered by patients with lesions of the brain and spinal cord. Some experiments of Tsukahara and Kawaguchi have been selected for review because they have demonstrated not only the histological evidence of regeneration, but also that it is functionally effective.

Keywords

Tungsten Neurol Dura Kato Alan 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Aguayo AJ, Benfey M, David S (1983) A potential for axonal regeneration in neurons of the adult mammalian nervous system. In: Haber B, Perez-Polo JR, Hashim GA, Giuffrida Stella AM (eds) Nervous system regeneration. Alan R. Liss, New York, pp 327–340Google Scholar
  2. 2.
    Edelman GM (1984) Modulation of cell adhesion during induction, histogenesis and prenatal development of the nervous system. Ann Rev Neurosci 7: 339–377PubMedCrossRefGoogle Scholar
  3. 3.
    Kawaguchi S, Yamamoto T, Samejima A, Itoh K, Mizuno N (1979 a) Morphological evidence for axonal sprouting of cerebello-thalamic neurons in kittens after neonatal hemicerebellectomy. Exp Brain Res 35: 511–518PubMedCrossRefGoogle Scholar
  4. 4.
    Kawaguchi S, Yamamoto T, Samejima A (1979b) Electrophysiological evidence for axonal sprouting of cerebellothalamic neurons in kittens after neonatal hemicerebellectomy. Exp Brain Res 36: 21–39PubMedCrossRefGoogle Scholar
  5. 5.
    Kawaguchi S, Miyata H, Kawamura M, Harada Y (1981) Morphological and electrophysiological evidence for axonal regeneration of axotomized cerebellothalamic neurons in kittens. Neurosci Lett 25: 13–18PubMedCrossRefGoogle Scholar
  6. 6.
    Kawaguchi S, Miyata H, Kato N (1982) Axonal regeneration of axotomized cerebellothalamic projection neurons in adult cats. J Physiol Soc Japan 44: 383Google Scholar
  7. 7.
    Kawaguchi S, Miyata H, Kato N (1984) Mechanical guidance for axonal regeneration of cerebellothalamic neurons in cat. Neurosci Lett [Suppl 17] 520Google Scholar
  8. 8.
    Kawaguchi S, Miyata H, Kato N (1986) Regeneration of the cerebellofugal projection after transection of the superior cerebellar peduncle in kittens: morphological and electrophysiological studies. J Comp Neurol 245: 258–273PubMedCrossRefGoogle Scholar
  9. 9.
    Murakami F, Katsumaru H, Saito K, Tsukahara N (1982) A quantitative study of synaptic reorganization in red nucleus neurons after lesions of the nucleus interpositus of the cat: an electron microscope study involving intracellular injection of horseradish peroxidase. Brain Res 242: 41–53PubMedCrossRefGoogle Scholar
  10. 10.
    Tsukahara N (1981) Synaptic plasticity in the mammalian central nervous system. Ann Rev Neurosci 4: 351–379PubMedCrossRefGoogle Scholar
  11. 11.
    Tsukahara N, Hultborn H, Murakami F (1974) Sprouting of corticorubral synapses in red nucleus neurones after destruction of the nucleus interpositus of the cerebellum. Experientia 30: 57–58CrossRefGoogle Scholar
  12. 12.
    Tsukahara N, Fujito Y, Kubota M (1983) Specificity of the newly formed corticorubral synapses in the kitten red nucleus. Exp Brain Res 51: 45–56PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • J. C. Eccles
    • 1
  1. 1.Max-Plank-Institut für Biologische ChemieGöttingenGermany

Personalised recommendations