CNS Peptides in Huntington’s Chorea

  • P. C. Emson
  • D. Dawbarn
  • M. E. de Quidt
Conference paper
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 4)

Abstract

Huntington’s chorea is a hereditary disease inherited as an autosomal dominant gene which produces progressive degeneration of the basal ganglia and, in particular, the caudate nucleus and putamen. As these CNS regions in other mammals are particularly rich in neuropeptides such as substance P and methionine-enkephalin, it was logical to look at the content of these peptides in Huntington’s disease to see if they could be used as biochemical markers for the degenerative changes characterizing this condition (see [5]).

Keywords

HPLC Filtration Dopamine Acetonitrile Fractionation 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • P. C. Emson
    • 1
  • D. Dawbarn
    • 1
  • M. E. de Quidt
    • 1
  1. 1.Department of Neuroendocrinology, Institute of Animal PhysiologyMRC GroupBabraham, CambridgeUK

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