Abstract
Numerous neurotransmitters are present in the basal ganglia. Knowledge of their distribution is one of the prerequisites for understanding the neurochemical organization of the basal ganglia and may eventually help to develop new strategies in the treatment of basal ganglia disorders. Based on (immuno-) histochemical studies, this article summarizes the known distribution of classical neurotransmitters and neuropeptides and the coexistence of neurotransmitters and neuropeptides in neuronal cell bodies of the rat basal ganglia. (For the distribution of neurotransmitters in afferents to the basal ganglia see the recent review by McGeer et al. [15]).
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References
Penny GR, Afsharpour S, Kitai ST (1986) The glutamate decarboxylase-, leucine enkephalin-, methionine enkephalin-and substance P-immuno reactive neurons in the neostriatum of the rat and cat: evidence for partial population overlap. Neurosci 17: 1011–1045
Agid Y, Javoy-Agid F (1985) Peptides and Parkinson’s disease. Trends in Neuroscience 8: 30–35
Andén NE, Carlsson A, Dahlström A, Fuze K, Hillarp NA, Larsson K (1964) Demonstration and mapping out of nigro-neostriatal dopamine neurons. Life Sci 3: 523–530
Aronin N, DiFiglia M, Graveland GA, Schwartz WJ, Wu J-Y (1984) Localization of immunoreactive enkephalins in GABA synthesizing neurons of the rat neostriatum. Brain Res 300: 376–380
Berod A, Hartmann BK, Keller R, Joh TH, Pujol JF (1982) A new double labeling technique using tyrosine hydroxylase and dopamine-beta-hydroxylase immunohistochemistry. Evidence for dopaminergic cells lying in the pons of the beef brain. Brain Res 240: 235–243
DiFiglia M, Aronin N (1982) Ultrastructural features of immunoreactive somatostatin neurons in the rat caudate nucleus. J Neurosci 9: 1267–1274
Eckenstein F, Barde YA, Thoenen H (1981) Production of specific antibodies to choline acetyltransferase purified from pig brain. Neuroscience 6: 993–1000
Fox CA, Andrade AN, Lu Qui IJ, Rafols JA (1974) The primate globus pallidus: a Golgi and electron microscope study. J Hirnforsch 15: 75–93
Freund TF, Powell JF, Smith AD (1984) Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons with particular reference to dendritic spines. Neuroscience 13: 1189–1215
Grace AA, Bunney BS (1979) Paradoxical excitation of nigral dopaminergic cells: indirect mediation through reticulata inhibitory neurons. Eur J Pharmacol 59: 211–218
Gramsch C, Meo T, Riethmüller G, Herz A (1983) Binding characteristics of a monoclonal ß-endorphin antibody recognizing the N-terminus of opioid peptides. J Neurochem 40: 12201226
Hökfelt T, Johansson O, Fuxe K, Goldstein M, Park D (1976) Immunohistochemical studies on the localization and distribution of monoamine neuron systems in the rat brain. I. Tyrosine hydroxylase in the mes-and diencephalon. Med Biol 54: 427–453
Hökfelt T, Skirboll L, Rehfeld JF, Goldstein M, Markey K, Dann O (1980) A subpopulation of mesencephalic dopamine neurons projecting to limbic areas contains a cholecystokininlike peptide: evidence from immunohistochemistry combined with retrograde tracing. Neuroscience 5: 2093–2124
Marsden CD, Sheehy MP (1981) GABA and movement disorders. In: Di Chiara G, Gessa GI (eds) GABA and the basal ganglia. Raven, New York, pp 225–234
McGeer E, Staines WA, McGeer PL (1984) Neurotransmitters in the basal ganglia. Can J Neurol Sci 11: 89–99
Morselli PL, Fournier V, Bossi L, Musch B (1985) Clinical activity of GABAergic agonists in neuroleptic and L-DOPA induced dyskinesia. In: Casey DE, Chase TN, Christensen AV, Gerlach J (eds) Dyskinesia: research and treatment. Springer, Berlin Heidelberg New York Tokyo, pp 128–136
Mugnaini E, Oertel WH (1985) An atlas of the distribution of GABAergic neurons and terminals in the rat CNS as revealed by GAD-immunohistochemistry. In: Björklund A, Hökfelt T (eds) Handbook of chemical neuroanatomy, vol 4, GABA and neuropeptides in the CNS, part I. Elsevier, Amsterdam, pp 436–608
Oertel WH, Mugnaini E (1984) Immunocytochemical studies of GABAergic neurons in rat basal ganglia and their relations to other neuronal systems. Neurosci Lett 47: 233–238
Oertel WH, Schmechel DE, Tappaz ML, Kopin IJ (1981) Production of a specific antiserum to rat brain glutamic acid decarboxylase by injection of an antigen-antibody complex. Neuroscience 6: 2689–2700
Oertel WH, Riethmüller G, Mugnaini E, Schmechel DE, Weindl A, Gramsch C, Herz A (1983) Opioid peptide-like immunoreactivity in GABAergic neurons of rat neostriatum and central amygdaloid nucleus. Life Sci [Suppl I] 33: 76–79
Oertel WH, Nitsch C, Mugnaini E (1984) The immunocytochemical demonstration of the GABAergic neurons in rat globus pallidus and nucleus entopeduncularis and their GABAergic innervation. Adv Neurol 40: 91–98
Penney JB Jr, Young AB (1982) Speculations on the functional anatomy of basal ganglia. Ann Rev Neurosci 6: 73–94
Sofroniew MV, Eckenstein F, Thoenen H, Cuello AC (1982) Topography of choline acetyltransferase-containing neurons in the forebrain of the rat. Neurosci Lett 33: 7–12
Staines WA, Oertel WH, Wu I-Y, Hökfelt T (1984) Immunohistochemistry of amino acid transmitter enzymes. Acta Neurol Scand 69: 306–312
Vincent S, Hökfelt T, Christensson I, Terenius L (1982) Immunohistochemical evidence for a dynorphin immunoreactive striatonigral pathway. Europ J Pharmacol 85: 251–252
Wassef M, Berod A, Sotelo C (1981) Dopaminergic dendrites in the pars reticulata of the rat substantia nigra and their striatal input. Combined immunocytochemical localization of tyrosine hydroxylase and anterograde degeneration. Neuroscience 6: 2125–2139
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© 1987 Springer-Verlag Berlin Heidelberg
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Oertel, W.H., Struppler, A. (1987). Immunohistochemical Studies on Neurotransmitters in Rat Basal Ganglia. In: Struppler, A., Weindl, A. (eds) Clinical Aspects of Sensory Motor Integration. Advances in Applied Neurological Sciences, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71540-2_25
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DOI: https://doi.org/10.1007/978-3-642-71540-2_25
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