Electrophysiological and Radiographic Evidence for the Mediation of Memory by an Anatomically Distributed System
A guiding principle in studies of brain-behavior relationships in general, and the mediation of memory in particular, has been that knowledge of the mediating anatomical structure often provides invaluable insight into how a function is performed. Recently, my colleagues and I have been using a double-labelled 2-deoxyglucose radioautographic technique to study the anatomical distribution of the metabolic correlates of memory activation in split-brain cats. Before presenting the results of these current studies, I will summarize the salient findings of our 35 years of prior research on this problem, so that our present metabolic studies can be integrated into the perspective of the preceding neurophysiological evidence.
KeywordsEntropy Phosphorus Cage Coherence Assimilation
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- Agranoff BW, Altenau LL (1977) A sequential double-labeled method for the measurement of radioactive 2-deoxyglucose phosphate distribution in the brain. Proc Int Soc Neurochem 6: 513–516Google Scholar
- John ER (1954) Functional brain mapping using radioactive tracers. PhD thesis, University of ChicagoGoogle Scholar
- John ER (1967) Mechanisms of memory. Academic, New YorkGoogle Scholar
- John ER (1972) Switchboard vs. statistical theories of learning and memory. Science 177: 850–864 John ER (1976) A modell of consciousness. In: Schwartz GE, Shapiro D (eds) Consciousness and self-regulation. Plenum, New York, pp 1–50Google Scholar
- John ER, Morgades PP (1969b) Patterns and anatomical distribution of evoked potentials and multiple unit activity elicited by conditioned stimuli in trained cats. Comm Behav Biol 3: 181–207Google Scholar
- Sokoloff L, Reivick M, Kennedy C, des Rosiers MH, Pattak CS, Pettigrew KD, Sukurada O, Shinohara H (1977) The [14C] deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28: 897–916PubMedCrossRefGoogle Scholar
- Sperry RW (1962) Some general aspects of cerebral integration. In: Mountcastle VB (ed) Interhemispheric relations and cerebral dominance. Johns Hopkins Press, Baltimore Thatcher R, John ER (1977) Foundations of cognitive processes.Google Scholar
- Erlbaum, Hillsdale Yonekurs Y, Brill AB, Som P, Bernett GW (1983) Quantitative autoradiography with radiopharmaceuticals. I. Digital filmanalysis system by videodensitometry: concise communication. J Nucl Med 24: 231–237Google Scholar