Abstract
Ten years ago, 3254 cases with primary liver cancer (PLC) in China were analyzed. The extremely high proportion of late stage patients with jaundice or ascites (52.6%), the extremely low series resection rate (5.3%), and the dismal ultimate outcome (1-year survival, 8.6%) revealed that PLC was indeed an enormous malignancy [23]. Every year, PLC causes 250 000 deaths in the world [29], 100 000 deaths in China [9], and 3000 deaths in Shanghai [3]. However, encouraging things have happened in China recently:
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1.
Hepatitis B virus (HBV), aflatoxin, contamination of drinking water, and other chemicals are considered to be etiological factors; identification of the transforming gene N-ras in PLC has been reported.
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2.
The concept of subclinical hepatocellular carcinoma (SCHCC) has been developed on the basis of alpha fetoprotein (AFP) serosurvey, involving a new approach to early detection, revision of the principles underlying surgical treatment, new insight into the natural history of hepatocellular carcinoma (HCC), and renewal of the prognostic concept, particularly with 5-year survival after resection of SCHCC up to 72.9% [19, 26].
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3.
Multimodality and aggressive approaches to the treatment of symptomatic PLC.
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4.
Establishment of human HCC cell lines and transplantable human HCC in immune-deficient animals.
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5.
More concern has been centered on the study of HCC cell membrane and its glycoprotein, glycolipid components in basic research.
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6.
Radioimmunodetection and radioimmunotherapy by using appropriate antibodies is also under way.
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Zhao-You, T., Ye-Qin, Y., Bing-Hui, Y. (1987). Subclinical Hepatocellular Carcinoma. In: Wagner, G., You-Hui, Z. (eds) Cancer of the Liver, Esophagus, and Nasopharynx. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71510-5_9
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DOI: https://doi.org/10.1007/978-3-642-71510-5_9
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