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The Role of Epstein-Barr Virus in Nasopharyngeal Carcinoma

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Cancer of the Liver, Esophagus, and Nasopharynx

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Abstract

Shortly after the discovery of the Epstein-Barr virus (EBV) in cultured Burkitt’s lymphoma (BL) cells, the association of the virus with another human malignant disease became apparent. Old et al. [21] noted first that patients with nasopharyngeal carcinoma (NPC) have unusually high antibody titers against viral antigens. This finding has since been widely confirmed and extended (for review, see [7, 10]). NPC is characterized by particular epidemiological features. It is the most frequent cancer in adult males in some parts of south China, with an age peak between 45 and 55 years. It occurs, however, with a lesser frequency all over the world. The Mediterranean countries are known as areas with an intermediate risk. Remarkably, there is a second peak at the age of 10–20 years for the occurrence of NPC outside China.

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Authors
  1. G. W. Bornkamm
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Editors and Affiliations

  1. Information und Statistik des Deutschen Krebsforschungszentrums, Institut für Dokumentation, Im Neuenheimer Feld 280, D-6900, Heidelberg 1, Germany

    Gustav Wagner

  2. Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Pan Jia Yao Zuo Anmen Wai, Beijing, P. R. China

    Zhang You-Hui (Director) (Director)

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© 1987 Springer-Verlag

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Bornkamm, G.W. (1987). The Role of Epstein-Barr Virus in Nasopharyngeal Carcinoma. In: Wagner, G., You-Hui, Z. (eds) Cancer of the Liver, Esophagus, and Nasopharynx. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71510-5_27

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  • DOI: https://doi.org/10.1007/978-3-642-71510-5_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16967-3

  • Online ISBN: 978-3-642-71510-5

  • eBook Packages: Springer Book Archive

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