Prospective Study of Serum VCA-IGA Antibody in the Normal Population in Guangdong Province of China

  • Li Chen-Chuan
  • Chen Ai-Mei
  • Liang Yi-Ren

Abstract

Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the Guangdong province of China. It represents 31.5% of all malignant tumors based on the hospital registry in this province [1]. A number of studies have demonstrated the higher serological reactivity to EBV-associated antigens among NPC patients compared with controls, independent of race and geography. Over 90% of NPC patients were positive for IgA antibodies to VCA at 1:10 dilution, as opposed to 0.6–6.0 in the control groups. GMTs of VCA-IgA were approximately 25-fold higher in NPC patients than in the various control groups [2]. But how about the EBV serology reactivity for normal individuals? There is very little information on this aspect.

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References

  1. 1.
    Li C-C: NPC Epidemiology, Risk Factors and Screening for Early Detection, in Marks PA (Edit.): New York: Grune & Stratton 1980Google Scholar
  2. 2.
    Li W-J et al.: Report on the Results of Serum VCA-IgA Detection by Using Immune Enzymatic Method for 1006 Cases of Pretreated Nasopharyngeal Carcinoma and 2114 Controls. WHO/WPRO Report of the Symposium on NPC, Guangzhou, China, Dec. 7–10, 1981. Manila 1982Google Scholar
  3. 3.
    Liu Y-X: Detection of EB Virus-Specific IgA Antibody from Patients with Nasopharyngeal Carcinoma by Immunoenzymic Method. J. Chinese Oncology 1 (1979) 8Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Li Chen-Chuan
  • Chen Ai-Mei
  • Liang Yi-Ren

There are no affiliations available

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