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In Vitro Effects of Iloprost on Platelet Aggregation in Normal and Hypercholesterolemia Subjects

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Prostacyclin and Its Stable Analogue Iloprost

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Abstract

Prostacyclin (PGI2) is a naturally occurring prostaglandin released by vascular tissues, which possesses platelet antiaggregatory and vasodilatory properties [1]. PGI2 interacts with specific receptors on platelets, and it increases intracellular cAMP levels through activation of the adenylate cyclase enzyme [2]. Platelets of patients suffering from pathological conditions associated with increased platelet aggregability displayed, in vitro, reduced sensitivity to the inhibitory effects of PGI2 [3, 4]. Previous studies by our group have shown that in patients with type Ila hypercholesterolemia, higher concentrations of PGI2 were required to inhibit the in vitro-induced platelet aggregation, in comparison with platelets from normolipidemic subjects [5]. The alterations observed in platelets from type Ila patients were not due to differences in the capability of PGI2 to stimulate platelet adenylate cyclase [5].

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Author information

Authors and Affiliations

  1. Pharmacology and Pharmacognosy Institute, University of Milan, Italy

    E. Tremoli, P. Maderna, L. Mannucci, S. Colli & R. Paoletti

Authors
  1. E. Tremoli
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  2. P. Maderna
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  3. L. Mannucci
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  4. S. Colli
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  5. R. Paoletti
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Copernicus Academy of Medicine, 16 Grzegórzecka, 31531, Cracow, Poland

    R. J. Gryglewski

  2. Cardiovascular Pharmacology, Schering AG, Müllerstraße 170–178, 1000, Berlin 65, Germany

    G. Stock

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© 1987 Springer-Verlag, Berlin Heidelberg

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Tremoli, E., Maderna, P., Mannucci, L., Colli, S., Paoletti, R. (1987). In Vitro Effects of Iloprost on Platelet Aggregation in Normal and Hypercholesterolemia Subjects. In: Gryglewski, R.J., Stock, G. (eds) Prostacyclin and Its Stable Analogue Iloprost. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71499-3_5

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  • DOI: https://doi.org/10.1007/978-3-642-71499-3_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71501-3

  • Online ISBN: 978-3-642-71499-3

  • eBook Packages: Springer Book Archive

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