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Effects of Iloprost on Platelet Activation In Vitro

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Prostacyclin and Its Stable Analogue Iloprost

Abstract

Iloprost has been shown to act via the PGI2 platelet receptor as an inhibitor of platelet activation in vitro and in vivo. The compound binds to the human platelet PGI2 receptor with a KD value of 0.6 x 10−7 M, the binding is highly specific and fully reversible.

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Authors and Affiliations

  1. Cardiovascular Pharmacology, Research Laboratories of Schering AG, Berlin, Germany

    C.-S. Stürzebecher & W. Losert

Authors
  1. C.-S. Stürzebecher
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  2. W. Losert
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Copernicus Academy of Medicine, 16 Grzegórzecka, 31531, Cracow, Poland

    R. J. Gryglewski

  2. Cardiovascular Pharmacology, Schering AG, Müllerstraße 170–178, 1000, Berlin 65, Germany

    G. Stock

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© 1987 Springer-Verlag, Berlin Heidelberg

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Stürzebecher, CS., Losert, W. (1987). Effects of Iloprost on Platelet Activation In Vitro. In: Gryglewski, R.J., Stock, G. (eds) Prostacyclin and Its Stable Analogue Iloprost. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71499-3_4

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  • DOI: https://doi.org/10.1007/978-3-642-71499-3_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71501-3

  • Online ISBN: 978-3-642-71499-3

  • eBook Packages: Springer Book Archive

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