The Reduction of Ultimate Infarct Size: State of the Art and Goals for the Future
The recognition that coronary artery disease constitutes a major threat to life in most developed nations has led to an intensified effort to identify and control those risk factors associated with premature cardiac mortality and morbidity. There is well documented experimental and clinical evidence to suggest that the extent of myocardial injury and ultimate myocardial cell death resulting from acute myocardial infarction strongly influences ultimate cardiac function and survival. Thus, efforts to minimize the amount of myocardial tissue becoming irreversibly injured in the course of an acute ischemic event have gained intensified interest. The most dramatic and potentially useful approach to the problem has been the restoration of coronary artery blood flow and the return of regional myocardial perfusion through the use of thrombolytic therapy. Coronary artery thrombolysis using streptokinase and perhaps human tissue plasminogen activator, because of its relative simplicity and high degree of success in achieving a lysis of the occlussive thrombus has gained acceptance in many countries of the world as the most useful method of restoring perfusion to the myocardium.
KeywordsHydrogen Peroxide Ischemia Superoxide Explosive Catalase
Unable to display preview. Download preview PDF.
- 4.Werns SW, Shea MJ, Driscoll EM, Cohen C, Abrams GD, Pitt B, Lucchesi BR (1985) The independent effects of oxygen radical scavengers on canine infarct size. Reduction by superoxide dismutase and not catalase. Circ Res 1: 103–110Google Scholar