Skip to main content
SpringerLink
Log in

Protective Effects of Iloprost Against Thromboxane-Induced Myocardial Infarction

  • Conference paper
Prostacyclin and Its Stable Analogue Iloprost

  • 79 Accesses

Abstract

The discovery of thromboxane A2 (TXA2) and prostacyclin, and the elucidation of their physiologic roles have brought new insights into atherogenesis and thrombogenesis [1–3]. In particular, the roles of these prostanoids in the pathogenesis of ischemic heart disease have recently been highlighted in relation to coronary thrombosis, vasospasm, and microcirculatory disturbances [4–7], and there has been much discussion regarding whether or not antiplatelet agents such as prostacyclin have preventive or curative effects in these conditions [8–11].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gryglewski RJ (1980) Prostaglandins, platelets and atherosclerosis. CRC Crit Rev Biochem 7: 291–338

    Article  PubMed  CAS  Google Scholar 

  2. Moncada S (1982) Prostacyclin and arterial wall biology. Arteriosclerosis 2: 193–207

    Article  PubMed  CAS  Google Scholar 

  3. Numano F (1981) Thromboxane A2 and atherosclerosis. In: de las Heras FG, Vega S (eds) Medicinal chemistry advances. Pergamon, Oxford, pp 131–140

    Google Scholar 

  4. Needleman P, Kalkarni PS, Raz A (1977) Coronary tone modulation; Formation and action of prostaglandins, endoperoxides and thromboxanes. Science 195: 409–412

    Article  PubMed  CAS  Google Scholar 

  5. Sobel M, Salzman EW, Davies GC, Handin RI, Sweeney J, Ploetz J, Kurland G (1981) Circulating platelet products in unstable angina pectoris. Circulation 63: 300–306

    Article  PubMed  CAS  Google Scholar 

  6. Moncada S, Vane JR (1982) Interrelationships between prostacyclin and thromboxane A2 metabolic activities of the lung. Ciba Foundation symposium’78. Excerpta Medica, Amsterdam, pp 165–183

    Google Scholar 

  7. Numano F, Nomura S, Aizawa T, Fujii J, Yajima M (1985) Prostacyclin and variant angina. Ann NY Acad Sci 454: 135–145

    Article  PubMed  CAS  Google Scholar 

  8. Moncada S (1983) Biology and therapeutic potential of prostacyclin. Stroke 14: 157–168

    Article  PubMed  CAS  Google Scholar 

  9. Numano F (1984) Cyclic nucleotides prostaglandins, and ischemic heart disease. In: Greengard P et al. (eds) Advances in cyclic nucleotides and protein phosphorylation research, vol 17. Raven, New York, pp 661–670

    Google Scholar 

  10. Vane JR (1983) Prostaglandins and the cardiovascular system. Brit Heart J 49: 405–409

    Article  PubMed  CAS  Google Scholar 

  11. Mehta J, Mehta P, Horalek C (1983) The sinificance of platelet-vessel wall prostaglandins equilibrium during exercise induced stress. Am Heart J 105: 895–900

    Article  PubMed  CAS  Google Scholar 

  12. Sasagawa S, Moriya K, Sugaya Y, Mitani J, Yajima M (1982) Effects of thromboxane A2 injection on the rabbit coronary artery. I. Physiological effects in healthy animals. Exp Mol Pathol 37: 111–117

    Article  PubMed  CAS  Google Scholar 

  13. Numano F, Yajima M, Nishiyama K, Shimokado K, Numano Fe, Sasagawa S, Moriya K (1982) Effects of thromboxane A2 injection on the rabbit coronary artery I. The production of infarcts in cholesterol fed animals. Exp Mol Pathol 37: 118–132

    Article  PubMed  CAS  Google Scholar 

  14. Numano F (1983) Prostaglandins, cyclic nucleotides and artherosclerosis. In: Schettler FG, Gotto AM, Middelhoff G, Habenicht HZE, Jurutka KR (eds) In: Atherosclerosis VI. Springer, Berlin Heidelberg New York, pp 704–707

    Google Scholar 

  15. Darius H (1985) Platelet and vascular effects of Iloprost (ZK 36374) and its stereoisomere ZK 36 375-two chemically stable prostacyclin analogues. In: Schrör K (ed) Prostaglandins and other eicosanoids in the cardiovascular system. Proceedings of the 2nd international symposium, Nürnberg-Fürth, 1984. Karger, Stuttgart, pp 454–464

    Google Scholar 

  16. Numano F, Omori K, Nishiyama K, Kishi Y, Shimokado K, Numano F, Yajima M, Maezawa H (1982) Plasma thromboxane B2 levels and atherosclerotic disorders. Paroi Arterielle-Arterial Wall/Par Arter VII: 99–106

    Google Scholar 

  17. Sekine M, Yajima M, Numano F (1985) Plasma 6-keto PGF1α levels in patients with vascular disorders. Vascular Med 3: 79–89

    Google Scholar 

  18. Numano F, Yajima M, Watanabe Y, Moriya K, Kuroiwa T, Shimokado K, Kishi Y, Maezawa H (1981) Microassay of cyclic nucleotides in vessel wall. V. Simultaneous assay of cyclic AMP and cyclic GMP. Exp Mol Pathol 34: 323–330

    Article  PubMed  CAS  Google Scholar 

  19. Lie JT, Holley KE, Kampa WR, Titus JL (1981) New histochemical method for morphologic diagnosis of early stages of myocardial ischemia. Mayo Clin Proc 46: 1210–1214

    Google Scholar 

  20. Takeuchi T, Kuriaki H (1955) Histochemical detection of Phosphorylase in animal tissues. J Histochem Cytochem 3: 153–160

    Article  PubMed  CAS  Google Scholar 

  21. Schrör K (1981) Possible role of prostaglandins in the regulation of coronary blood flow. Basic Res Cardiol 76: 239–249

    Article  PubMed  Google Scholar 

  22. Hirsch PD, Hills LD, Campbell WB, Firth BG, Willerson JT (1981) Release of prostaglandins and thromboxane into coronary circulation in patients with ischemic heart disease. N Engl J Med 304: 685–691

    Article  Google Scholar 

  23. Lewy RI, Wiener L, Walinsky P, Lefer AM, Silver MJ, Smith JB (1980) Thromboxane release during pacing-induced angina pectoris: possible vasoconstrictor influence on the coronary vasculature. Circulation 61: 1165–1171

    PubMed  CAS  Google Scholar 

  24. Yajima M, Nomura S, Namba K, Sekine M, Hosaka T, Numano F (1985) Plasma thromboxane B2, 6-keto PGF1α and cyclic nucleotides levels as related to treadmill exercise test in patients with ischemic heart disease. Jpn Circ J 49: 38–45

    Article  PubMed  CAS  Google Scholar 

  25. Numano F (1982) Antiplatelet therapy for ischemic heart disease. XI. world congress of cardiology, June 22, Moscow

    Google Scholar 

  26. Schrör K, Thiemermann C, Thomsen T, Ohlendorf R, Darius H, Gallenkämper W, Smith III EF (1984) Beneficial effect of iloprost in experimental myocardial infarction. In: Iloprost a novel prostacyclin analogue in cardiovascular disease. Scientific symposium, Düsseldorf. Schering AG, Berlin, pp 16–29

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, Japan

    F. Numano, T. Koyama, K. Moriya, K. Nishiyama, K. Shimokado, Y. Kishi & M. Yajima

Authors
  1. F. Numano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Koyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Moriya
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Nishiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Shimokado
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Y. Kishi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M. Yajima
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pharmacology, Copernicus Academy of Medicine, 16 Grzegórzecka, 31531, Cracow, Poland

    R. J. Gryglewski

  2. Cardiovascular Pharmacology, Schering AG, Müllerstraße 170–178, 1000, Berlin 65, Germany

    G. Stock

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag, Berlin Heidelberg

About this paper

Cite this paper

Numano, F. et al. (1987). Protective Effects of Iloprost Against Thromboxane-Induced Myocardial Infarction. In: Gryglewski, R.J., Stock, G. (eds) Prostacyclin and Its Stable Analogue Iloprost. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71499-3_24

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71499-3_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71501-3

  • Online ISBN: 978-3-642-71499-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation