Actions of Prostaglandins on the Heart

  • K. Schrör


Prostaglandin synthetase activity in cardiac microsomal fractions was originally described in 1973 by Limas and Cohn [1]. This finding indicated that prostaglandins, which can affect myocardial contraction and, especially, coronary perfusion, are generated by the heart itself, i.e., cardiac muscle cells, the interstitium, and coronary vessels. Formation of all the major products of arachidonic acid peroxidation, including thromboxane A2 (TXA2) [2], prostacyclin (PGI2) [3, 4] and leukotrienes [5, 6] has been demonstrated in the heart and coronary vessels. The heart is not only able to generate eicosanoids but is also a major target for them. Thus eicosanoids, either synthesized by the heart itself or released from other organs and tissues (especially the lungs, platelets, and white cells) might act on the heart and the coronary circulation and significantly modify the cardiac output.


Coronary Perfusion Tiaprofenic Acid Cardiac Sympathetic Nerve Coronary Artery Ligation Coronary Vascular Resistance 
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Copyright information

© Springer-Verlag, Berlin Heidelberg 1987

Authors and Affiliations

  • K. Schrör
    • 1
  1. 1.Pharmakologisches Institut der Universität KölnKölnGermany

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