Abstract
The naturally occurring prostacyclin (PGI2) is a highly potent vasodilator and effectively lowers blood pressure in experimental animals when applied intravenously. Prostacyclin has, however, the disadvantage that it rapidly deteriorates at physiological pH and at normal room temperature. When PGI2 is applied orally, it has no systemic effect as it is very rapidly disintegrated in the gastric juices.
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References
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© 1987 Springer-Verlag, Berlin Heidelberg
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Haberey, M., Loge, O., Maaß, B., Ohme, G. (1987). Hemodynamic Profile of Iloprost in Rats, Rabbits and Cats. In: Gryglewski, R.J., Stock, G. (eds) Prostacyclin and Its Stable Analogue Iloprost. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71499-3_18
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DOI: https://doi.org/10.1007/978-3-642-71499-3_18
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71501-3
Online ISBN: 978-3-642-71499-3
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