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Studies on Vasorelaxant Effects and Mechanisms of Iloprost in Isolated Preparations

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Prostacyclin and Its Stable Analogue Iloprost

Abstract

PGI2, the main cyclo-oxygenase product generated by blood vessels [14], is known to possess powerful vasodilatory properties in different vascular beds [10, 22]. Iloprost is slightly more active than PGI2 in relaxing isolated strips from bovine coronary arteries and rabbit arteries which are commonly used as bioassay systems for PGI2-mimetic vasorelaxing properties [2, 3, 5]. The PGI2-induced alterations in vascular tone seem to be mediated by specific vascular receptor sites. Iloprost binds specifically and reversibly to prostacyclin-like receptors in various preparations including vascular smooth muscle [19, 23]. Whether the interaction of PGI2 with the vascular PGI2 receptor is followed by an activation of adenylate cyclase and an increase in cAMP is still controversial [4, 12, 15, 18, 20].

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Author information

Authors and Affiliations

  1. Research Laboratories of Schering AG, Berlin, Germany

    G. Schröder, R. Beckmann & E. Schillinger

Authors
  1. G. Schröder
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  2. R. Beckmann
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  3. E. Schillinger
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Copernicus Academy of Medicine, 16 Grzegórzecka, 31531, Cracow, Poland

    R. J. Gryglewski

  2. Cardiovascular Pharmacology, Schering AG, Müllerstraße 170–178, 1000, Berlin 65, Germany

    G. Stock

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© 1987 Springer-Verlag, Berlin Heidelberg

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Schröder, G., Beckmann, R., Schillinger, E. (1987). Studies on Vasorelaxant Effects and Mechanisms of Iloprost in Isolated Preparations. In: Gryglewski, R.J., Stock, G. (eds) Prostacyclin and Its Stable Analogue Iloprost. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71499-3_15

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  • DOI: https://doi.org/10.1007/978-3-642-71499-3_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71501-3

  • Online ISBN: 978-3-642-71499-3

  • eBook Packages: Springer Book Archive

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