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Profile of Generation of Eicosanoids by Blood Vessels and the Heart

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Prostacyclin and Its Stable Analogue Iloprost

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Abstract

In the vessel wall arachidonic acid, the major precursor of eicosanoid biosynthesis in mammalian tissues, is mainly metabolized via the cyclo-oxygenase pathway. In the endothelial or smooth muscle layers of the blood vessel wall, arachidonic acid is preferentially converted to prostaglandin (PG)I2, which is a potent vasodilator and inhibitor of platelet aggregation [32]. In blood platelets, on the other hand, arachidonic acid is preferentially converted via cyclo-oxygenase and thromboxane (TX) synthetase to TXA2, a vasoconstrictor and potent inducer of platelet aggregation [22]. On the basis of these facts a TXA2-PGI2 balance had been proposed, offering a concept for the participation of eicosanoids in normal hemostasis and in pathological conditions [32]. This hypothesis has stimulated an abundance of basic and clinical research, even though the importance of PGI2 has recently been questioned [26].

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Ruhr University, Bochum, Germany

    Th. Simmet & B. A. Peskar

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  1. Th. Simmet
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  2. B. A. Peskar
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Copernicus Academy of Medicine, 16 Grzegórzecka, 31531, Cracow, Poland

    R. J. Gryglewski

  2. Cardiovascular Pharmacology, Schering AG, Müllerstraße 170–178, 1000, Berlin 65, Germany

    G. Stock

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© 1987 Springer-Verlag, Berlin Heidelberg

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Simmet, T., Peskar, B.A. (1987). Profile of Generation of Eicosanoids by Blood Vessels and the Heart. In: Gryglewski, R.J., Stock, G. (eds) Prostacyclin and Its Stable Analogue Iloprost. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71499-3_14

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  • DOI: https://doi.org/10.1007/978-3-642-71499-3_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71501-3

  • Online ISBN: 978-3-642-71499-3

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